Anti-Human NOTCH1 Recombinant Antibody (Brontictuzumab)

Name: Anti-Human NOTCH1 Recombinant Antibody (Brontictuzumab)
SKU: TAB-H11
Rating: 5 (1 reviews)

CAT#: TAB-H11

Recombinant Humanized (from mouse) antibody to Human NOTCH1

Tested Data Gene Expression

SDS-PAGE

Figure 1 Anti-Human NOTCH1 Recombinant Antibody in SDS-PAGE

Lane M: Protein Marker Lane 1: Non-Reducing (2.0 μg) Lane 2: Reducing (2.0 μg)

❮

❯

Subcellular Location Figure 1 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg

Normal Tissue Figure 2 IHC staining of human pancreas

Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg

Normal Tissue Figure 4 Colon

Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg

Normal Tissue Figure 6 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg

Normal Tissue Figure 7 Testis

Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg

Normal Tissue Figure 8 Lymph node

Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1

❮

❯

Specifications

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG2 - lambda

Specificity
NOTCH1 (notch 1, translocation-associated notch-1, TAN-1, TAN1) [Homo sapiens]

Species Reactivity
Human

Applications
Inhib

CAS
1447814-75-6

Generic Name
brontictuzumab

Related Disease
Lymphoma

Product Property

Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Applications

Application Notes
The Human NOTCH1 antibody has been reported in applications of Inhibition.
Inhib: 10 mg/kg.

Target

Alternative Names
brontictuzumab;1447814-75-6;N248A ;NOTCH1;notch 1;Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1;neurogenic locus notch homolog protein 1;Notch homolog 1, translocation-associated;tr

Gene ID
4851

UniProt ID
P46531

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for TAB-H11. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Biosimilar Overview

Please refer to Brontictuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Brontictuzumab.

Related Diseases

Breast Cancer

Endocrine Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-H11.pdf

MSDS

MSDS - TAB-H11.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Brontictuzumab"

Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H11)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human NOTCH1

DrugMonitor™ Anti-Brontictuzumab Antibody (VS-1224-YC226)
Brontictuzumab has been used in trials for treating Adenoid Cystic Carcinoma, relapsed or refractory solid tumors, and relapsed or refractory lymphoid malignancies. The DrugMonitor™ Anti-Brontictuzumab Antibody (VS-1224-YC226) is an anti-drug antibody (ADA) against Brontictuzumab. This drug-based antibody is raised in mice immunized with the Brontictuzumab. The anti-Brontictuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Brontictuzumab in samples.

See other products for "NOTCH1"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-1747z	Mouse Anti-NOTCH1 Recombinant Antibody (clone 21H9)	WB, ICC, IF, IHC	Mouse IgG2b
HPAB-0078-YC	Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51)	IHC	Mouse IgG
FN-101CQ	Recombinant Armenian hamster Anti-NOTCH1 Antibody (HMN1-12)	FC, IHC	Armenian Hamster IgG
FAMAB-1388CQ	Mouse Anti-NOTCH1 Recombinant Antibody (clone E6)	Inhib, Block, ELISA, IF	Mouse IgG1
ZG-0032U	Rabbit Anti-NOTCH1 Recombinant Antibody (clone 4F6)	ELISA, WB, IHC	Rabbit IgG

CAT	Product Name	Application	Type
PFBL-660	Human Anti-NOTCH1 Recombinant Antibody; Fab Fragment	ELISA	Human Fab
NS-060CN-F(E)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); Fab Fragment	FC, IF, ELISA	Mouse Fab
NS-061CN-F(E)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); Fab Fragment	FC, IF, ELISA	Mouse Fab
NS-062CN-F(E)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); Fab Fragment	FC, IF, ELISA	Mouse Fab
HPAB-0044LY-F(E)	Mouse Anti-NOTCH1 Recombinant Antibody; Fab Fragment (HPAB-0044LY-F(E))	WB	Mouse Fab

CAT	Product Name	Application	Type
PSBL-660	Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment	ELISA	Human scFv
NS-060CN-S(P)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); scFv Fragment	FC, IF, ELISA	Mouse scFv
NS-061CN-S(P)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); scFv Fragment	FC, IF, ELISA	Mouse scFv
NS-062CN-S(P)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); scFv Fragment	FC, IF, ELISA	Mouse scFv
HPAB-AP750-YC-S(P)	Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); scFv Fragment	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
TAB-541MZ	Human Anti-NOTCH1 Recombinant Antibody (TAB-541MZ)	Neut, WB	Humanized antibody
TAB-541MZ-S(P)	Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-541MZ-S(P))	WB, Competition ELISA	Humanized scFv
TAB-542MZ-S(P)	Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-542MZ-S(P))	WB, Competition ELISA	Humanized scFv
TAB-544MZ-S(P)	Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (A12.2)	ELISA, WB, Luciferase reporter assay	Humanized antibody
PABX-152-S (P)	Recombinant Human Anti-NRR1 Antibody scFv Fragment	ELISA, Neut, FuncS	scFv

CAT	Product Name	Application	Type
TAB-543MZ	Anti-Human NOTCH1 Recombinant Antibody (mAb N248A)	ELISA, WB, Luciferase reporter assay
TAB-539MZ-S(P)	Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-539MZ-S(P))	WB, Competition ELISA	Rat scFv
TAB-540MZ-S(P)	Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-540MZ-S(P))	WB, Competition ELISA	Rat scFv
TAB-543MZ-S(P)	Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (mAb N248A)	ELISA, WB, Luciferase reporter assay
TAB-539MZ-F(E)	Rat Anti-NOTCH1 Recombinant Antibody; Fab Fragment (TAB-539MZ-F(E))	WB, Competition ELISA	Rat Fab

CAT	Product Name	Application	Type
TAB-545MZ	Anti-Human NOTCH1 Recombinant Antibody (23814)	ELISA, FuncS, Inhib, WB, FACS	Human antibody
TAB-546MZ	Anti-Human NOTCH1 Recombinant Antibody (23418.8)	FuncS, Inhib	Human antibody
TAB-547MZ	Human Anti-NOTCH1 Recombinant Antibody (TAB-547MZ)	Inhib	Human IgG1
TAB-548MZ	Human Anti-NOTCH1 Recombinant Antibody (TAB-548MZ)	FuncS, Inhib	Human IgG1
TAB-549MZ	Human Anti-NOTCH1 Recombinant Antibody (TAB-549MZ)	Inhib	Human IgG1

CAT	Product Name	Application	Type
NEUT-1786CQ	Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519)	FC, BL	IgG1, κ

CAT	Product Name	Application	Type
MOR-2473	Hi-Affi™ Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (DS2473AB)	WB, IHC	IgG

CAT	Product Name	Application	Type
NS-060CN	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6)	FC, IF, ELISA, Inhib, FuncS	Mouse IgG1
NS-061CN	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10)	FC, IF, ELISA	Mouse IgG1
NS-062CN	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11)	FC, IF, ELISA, Inhib	Mouse IgG2b
NS-063CN-F(E)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); Fab Fragment	FC, IF, ELISA	Mouse Fab
NS-063CN-S(P)	Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); scFv Fragment	FC, IF, ELISA	Mouse scFv

CAT	Product Name	Application	Type
AFC-TAB-H11	Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H11)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0924-YC79	Rabbit Anti-NOTCH1 Antibody (VS-0924-YC79) - Cancer Stem Cell Marker	IF	Rabbit IgG

CAT	Product Name	Application	Type
VS-1024-XY345	Mouse Anti-NHP NOTCH1 Recombinant Antibody (clone mN1A)	ELISA	Mouse IgG1

CAT	Product Name	Application	Type
VS13-YC828	CytoStream™ Rabbit Anti-NOTCH1 Recombinant Antibody (VS13-YC828)	WB, ICC, IF, IHC-P, IP, FC	Rabbit IgG
VS13-YC829	CytoStream™ Rabbit Anti-NOTCH1 Polyclonal Antibody (VS13-YC829)	WB, IHC, IF, FC	Rabbit IgG

CAT	Product Name	Application	Type
VS-0425-FY159	Human Anti-NOTCH1 scFv-Fc Chimera (VS-0425-FY159)	ELISA, Inhib, WB, FC	Human IgG1, scFv-Fc

CAT	Product Name	Application
VS-0325-XY1506	Anti-NOTCH1 Immunohistochemistry Kit	IHC
VS-0525-XY4907	Anti-Mouse NOTCH1 Immunohistochemistry Kit	IHC
VS-0525-XY4906	Anti-Human NOTCH1 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0425-YC381	Recombinant Anti-NOTCH1 Vesicular Antibody, EV Displayed (VS-0425-YC381)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-YC139	Recombinant Anti-NOTCH1 (LBD domain x HD-LNR domain) Biparatopic Antibody, Tandem scFv (Clone hN1wc49 x Clone N1wc104)	ELISA	Tandem scFv

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 1 Anti-Human Abeta Antibody in SDS-PAGE

Anti-Human Abeta Recombinant Antibody (Solanezumab) (CAT# TAB-228)
Application: WB, FuncS, IF, Neut, ELISA, FC, IP

Figure 2 Anti-CAIX/CA9 Antibody (TAB-707) in WB

Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) (CAT# TAB-707)
Application: WB, FuncS, IF, Neut, ELISA, FC, IP

Figure 3 Llama Anti-human IgG-CH1 VHH Single Domain Antibody (VHH-His-Cys) (NABG-112-UN) in DB

Llama Anti-human IgG-CH1 VHH Single Domain Antibody [Biotin] (CAT# NABG-112)
Application: ELISA, WB, BLI, SPR

Figure 1 Anti-Human ACVRL1 Recombinant Antibody (TAB-013CL) in SDS-PAGE

Anti-Human ACVRL1 Recombinant Antibody (TAB-013CL) (CAT# TAB-013CL)
Application:

Figure 1 Anti-Human ENG Recombinant Antibody (TAB-232CL) in SDS-PAGE

Anti-Human ENG Recombinant Antibody (TAB-232CL) (CAT# TAB-232CL)
Application:

Figure 2 Anti-Influenza Virus M2e Antibody (TAB-508CL) in HPLC

Anti-Influenza Virus M2e Recombinant Antibody (TCN-032) (CAT# TAB-508CL)
Application: FuncS

Figure 2 Human IL31 Recombinant Antibody (AFC-409CL) in ELISA

Afuco™ Anti-Human IL31 ADCC Recombinant Antibody (BMS-981164), ADCC Enhanced (CAT# AFC-409CL)
Application:

Figure 2 Recombinant Anti-1,3-Beta-glucan Antibody (MOB-0228MC) in HPLC

Recombinant Anti-1,3-Beta-glucan Antibody (CAT# MOB-0228MC)
Application: ELISA, WB, IP, FuncS

Figure 2 Anti-LPA Recombinant Antibody (TAB-0340CL) in HPLC

Anti-LPA Recombinant Antibody (LT3015 [B7(LT3000, Lpathomab)]) (CAT# TAB-0340CL)
Application: ELISA, SPR, Inhib, FuncS

Figure 1 Anti-CD3 Antibody (TAB-0416CL) Induced PBMCs Proliferation

Mouse Anti-CD3 Recombinant Antibody (TAB-0416CL) (CAT# TAB-0416CL)
Application: FC, IB, ELISA

Figure 3 Anti-Human CD34 Recombinant Antibody (TAB-150LC) in ELISA

Human Anti-CD34 Recombinant Antibody (TAB-150LC) (CAT# TAB-150LC)
Application: ELISA

Figure 2 Anti-Human FAP Antibody (TAB-024WM) in ELISA

Human Anti-FAP Recombinant Antibody (TAB-024WM) (CAT# TAB-024WM)
Application: IHC, ELISA, FC, IF

Figure 1 Anti-Human RNF43 Recombinant Antibody (TAB-327CT) in SDS-PAGE

Mouse Anti-RNF43 Recombinant Antibody (TAB-327CT) (CAT# TAB-327CT)
Application: WB, ELISA, FC, IHC, IP

Figure 1 Anti-CD20 Antibody (PABX-028) in Flow Cytometry

Recombinant Human Anti-CD20 Antibody (PABX-028) (CAT# PABX-028)
Application: WB, ELISA, IF, FuncS, Apop, BA

Figure 5 Rabbit Anti-T7 RNA Polymerase Antibody, HRP (MOB-0296MC-HRP) in Dot Blot

Rabbit Anti-T7 RNA Polymerase Antibody (CAT# MOB-0296MC)
Application: ELISA, WB

Figure 2 Anti-Human ERBB2 Protein Antibody in ELISA

Mouse Anti-ERBB2 Recombinant Antibody (MOB-014LC) (CAT# MOB-014LC)
Application: ELISA, FC

Figure 4 Mouse Anti-PSCA Recombinant Antibody (HPAB-0287CQ) in WB

Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11) (CAT# HPAB-0287CQ)
Application: FC, IHC, Cyt, FuncS

Figure 5 Mouse Anti-VEGFA Recombinant Antibody (clone mAb G6-31) (HPAB-0330CQ) in DB

Mouse Anti-VEGFA Recombinant Antibody (clone mAb G6-31) (CAT# HPAB-0330CQ)
Application: ELISA, IF, Block, FuncS

Figure 4 Human Anti-CD3 Recombinant Antibody (HPAB-M0467-YC-S(P)) in FACS

Human Anti-CD3 Recombinant Antibody scFv Fragment (HPAB-M0467-YC-S(P)) (CAT# HPAB-M0467-YC-S(P))
Application: FC

Figure 4 Human Anti-PEG Recombinant Antibody (FAMAB-1525CQ) in ELISA

Human Anti-PEG Recombinant Antibody (clone E11) (CAT# FAMAB-1525CQ)
Application: WB, ELISA, FC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.