The anti-Notch1 antibody 2D11 can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of Notch1.
Figure 1 A histogram summarizing results of an experiment to determine specificity of antibody binding to human Notch 1 on the surface of CHO-Flpln-Notchl cells.
Antibodies 2G10, 2E6 (also referred to herein as antibody 2E06), 2A11, and 2D11 are shown from left to right.
Figure 2 A histogram summarizing results of Notch 1-specific reporter assays showing that antibody 2D11 inhibits Notch 1-dependent reporter gene expression induced by the ligands Jagl, Jag2, DLL1 and DLL4.
Reporter activity in the absence of any activating ligand (Fc + mlgG) was defined as 100% inhibition, and activity in the presence of ligand and treated with mouse IgG (Ligand alone + mlgG) was defined as 0% inhibition.
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• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
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• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H11 | Anti-Human NOTCH1 Recombinant Antibody (Brontictuzumab) | Inhib | IgG2 - lambda |
TAB-541MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-541MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
TAB-542MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-542MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
TAB-544MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (A12.2) | ELISA, WB, Luciferase reporter assay | Humanized antibody |
TAB-544MZ-F(E) | Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (A12.2) | ELISA, WB, Luciferase reporter assay | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-666 | Human Anti-NOTCH1 Recombinant Antibody | ELISA | Human IgG |
MOB-1438CT | Recombinant Mouse anti-Mouse NOTCH1 Monoclonal antibody (3E12) | FC | |
HPAB-0044LY | Mouse Anti-NOTCH1 Recombinant Antibody (HPAB-0044LY) | WB | Mouse IgG1 |
HPAB-0085-YJ | Rat Anti-NOTCH1 Recombinant Antibody (clone bTAN 20) | IF, IHC, WB | Rat IgG1, κ |
HPAB-0681-WJ | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51) | ELISA, WB | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-660 | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment | ELISA | Human scFv |
HPAB-0078-YC-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51); scFv Fragment | IHC | Mouse scFv |
HPAB-0044LY-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody; scFv Fragment (HPAB-0044LY-S(P)) | WB | Mouse scfv |
HPAB-0681-WJ-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); scFv Fragment | ELISA, WB | Humanized scFv |
HPAB-AP750-YC-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); scFv Fragment | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-539MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-539MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
TAB-540MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-540MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
TAB-539MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-539MZ-S(P)) | WB, Competition ELISA | Rat scFv |
TAB-540MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-540MZ-S(P)) | WB, Competition ELISA | Rat scFv |
TAB-543MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (mAb N248A) | ELISA, WB, Luciferase reporter assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-545MZ | Anti-Human NOTCH1 Recombinant Antibody (23814) | ELISA, FuncS, Inhib, WB, FACS | Human antibody |
TAB-546MZ | Anti-Human NOTCH1 Recombinant Antibody (23418.8) | FuncS, Inhib | Human antibody |
TAB-547MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-547MZ) | Inhib | Human IgG1 |
TAB-548MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-548MZ) | FuncS, Inhib | Human IgG1 |
TAB-549MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-549MZ) | Inhib | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1786CQ | Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) | FC, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2473 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (DS2473AB) | WB, IHC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-060CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6) | FC, IF, ELISA, Inhib, FuncS | Mouse IgG1 |
NS-061CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10) | FC, IF, ELISA | Mouse IgG1 |
NS-062CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11) | FC, IF, ELISA, Inhib | Mouse IgG2b |
NS-063CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); Fab Fragment | FC, IF, ELISA | Mouse Fab |
NS-063CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-060CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); Fab Fragment | FC, IF, ELISA | Mouse Fab |
NS-061CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); Fab Fragment | FC, IF, ELISA | Mouse Fab |
NS-062CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); Fab Fragment | FC, IF, ELISA | Mouse Fab |
HPAB-0044LY-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody; Fab Fragment (HPAB-0044LY-F(E)) | WB | Mouse Fab |
HPAB-0681-WJ-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); Fab Fragment | ELISA, WB | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H11 | Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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