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  • Human Anti-NOTCH1 Recombinant Antibody; Fab Fragment

Human Anti-NOTCH1 Recombinant Antibody; Fab Fragment (CAT#: PFBL-660)

Recombinant Human Antibody is capable of binding to NOTCH1 NRR, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-NOTCH1 NRR fab and CH1-3 region of human fab and a light chain (LC) encoding VL from anti-NOTCH1 NRR proteins fab and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody holds the promise of simultaneously targeting cancers by directly inhibiting cancer cell growth and disrupting tumour angiogenesis.

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Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67168/1315_F7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Figure 2 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22466/61564_A_3_3_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Fibroblasts Staining: High Intensity: Strong Mucosal lymphoid cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_3.jpg
Figure 5 Liver
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_8_5.jpg
Figure 7 Testis
Figure 7 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_6_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8112/61559_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
Figure 9 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2, HMC-1, MOLT-4)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148400-NOTCH1

Specifications

  • Immunogen
  • Human notch 1
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human Fab
  • Specificity
  • Human NOTCH1
  • Species Reactivity
  • Human
  • Applications
  • ELISA

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • NOTCH1; notch 1; hN1; AOS5; TAN1; AOVD1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "NOTCH1"

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IgG Antibody Products Mouse Antibody Products Humanized Antibody Products Human Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products Neuroscience Antibody Products Fab Antibody Products ADCC Enhanced Antibody Products ScFv Antibody Products Cancer Stem Cell Biomarker Specific Antibody Products Non-Human Primate (NHP) Antibody Products
CAT Product Name Application Type
MOB-1747z Mouse Anti-NOTCH1 Recombinant Antibody (clone 21H9) WB, ICC, IF, IHC Mouse IgG2b
HPAB-0044LY Mouse Anti-NOTCH1 Recombinant Antibody (HPAB-0044LY) WB Mouse IgG1
FN-101CQ Recombinant Armenian hamster Anti-NOTCH1 Antibody (HMN1-12) FC, IHC Armenian Hamster IgG
FAMAB-1388CQ Mouse Anti-NOTCH1 Recombinant Antibody (clone E6) Inhib, Block, ELISA, IF Mouse IgG1
VS3-CJ976 Rabbit Anti-NOTCH1 Recombinant Antibody (VS3-CJ976) WB, ICC, IF, IHC, IP, FC Rabbit IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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