Recombinant Anti-PRNP Vesicular Antibody, EV Displayed (VS-0425-YC520)
CAT#: VS-0425-YC520
The Recombinant Anti-PRNP Vesicular Antibody, EV Displayed (VS-0425-YC520) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PRNP-expressed cells or tissues. PRNP is a glycosylphosphatidylinositol-anchored glycoprotein with regions prone to aggregation. Mutations in PRNP are linked to diseases like Creutzfeldt-Jakob and fatal familial insomnia. An overlapping open reading frame produces a smaller protein, AltPrP.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_B_7_5.jpg
Normal Tissue
Figure 4 Caudate
Neuronal cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/95554_B_9_7.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_A_9_3.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171867-PRNP
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PRNP
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Prion protein
- Biological Process
- Cell cycle, Growth arrest
- Molecular Function
- Prion
- Cellular Localization
- Nuclear membrane, Cytosol, Vesicles
- Introduction
- The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp.
- Alternative Names
- AltPrP, CD230, CJD, GSS, PRIP, PRP
- Gene ID
- 5621
- UniProt ID
- P04156
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Datasheet
MSDS
COA
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|---|---|---|---|
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| IAB-B034(T) | Recombinant Anti-human PRNP Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-026 | Recombinant Anti-Human PRNP VHH Single Domain Antibody (PNBL-026) | WB, ELISA, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-089 | Mouse Anti-PRNP Recombinant Antibody (clone 3F4) | ELISA | Mouse IgG2a |
| FAMAB-0272CQ | Human Anti-PRNP Recombinant Antibody (clone ch31C6) | ELISA, WB, IHC | Chimeric (mouse/human) IgG1 |
| FAMAB-0273CQ | Mouse Anti-PRNP Recombinant Antibody (clone mAb 106) | ELISA, WB, IHC | Mouse IgG2b, κ |
| FAMAB-0274CQ | Mouse Anti-PRNP Recombinant Antibody (clone mAb 110) | ELISA, WB, IHC | Mouse IgG2a, κ |
| FAMAB-0275CQ | Mouse Anti-PRNP Recombinant Antibody (clone mAb 132) | ELISA, WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-953LC | Anti-Human PRNP Recombinant Antibody (1A1) | FuncS, FC | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-942LC-S(P) | Anti-Sheep PRNP Recombinant Antibody scFv Fragment (6.1) | ELISA | Mouse antibody |
| MRO-948LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (6H10) | ELISA | Mouse antibody |
| MRO-949LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (31C6) | ELISA | Mouse antibody |
| MRO-950LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (72-5) | ELISA | Mouse antibody |
| MRO-951LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (44B1) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-943LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (D13) | ELISA | Human antibody |
| MRO-944LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (D18) | ELISA | Human antibody |
| MRO-945LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (R72) | ELISA | Human antibody |
| MRO-946LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (R1) | ELISA | Human antibody |
| MRO-947LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (R2) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0727MZ | Chicken Anti-PRNP Polyclonal IgY | ICC, IF | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2871 | Hi-Affi™ Recombinant Rabbit Anti-PRNP Monoclonal Antibody (DS2871AB) | WB, FC, IHC-P, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0050-CN-S(P) | Chicken Anti-PRNP Recombinant Antibody (clone phAb4-31); scFv Fragment | ELISA | Chicken scFv |
| FAMAB-0051-CN-S(P) | Human Anti-PRNP Recombinant Antibody (clone hu4.00); scFv Fragment | ELISA | Humanized scFv |
| FAMAB-0052-CN-S(P) | Chicken Anti-PRNP Recombinant Antibody (clone ch4.31); scFv Fragment | ELISA | Chicken scFv |
| FAMAB-0053-CN-S(P) | Human Anti-PRNP Recombinant Antibody (clone hu4.15); scFv Fragment | ELISA | Human scFv |
| FAMAB-0054-CN-S(P) | Human Anti-PRNP Recombinant Antibody (clone hu4.44); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0282CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone boPrP-15); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0283CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone huPrP-18); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0284CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone huPrP-39); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0285CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone boPrP-20); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0909-FY-S(P) | Mouse Anti-PRNP Recombinant Antibody scFv Fragment (HPAB-0909-FY-S(P)) | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY84 | Human Anti-PRNP (clone mAb132) scFv-Fc Chimera | ELISA, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1763 | Anti-PRNP Immunohistochemistry Kit | IHC | |
| VS-0525-XY5727 | Anti-Human PRNP Immunohistochemistry Kit | IHC | |
| VS-0525-XY5728 | Anti-Mouse PRNP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC150 | Recombinant Anti-PRNP (AA 56-90 x AA 83-89) Biparatopic Antibody, Tandem scFv (mAb 106 x mAb 110) | ELISA, IHC, WB | Tandem scFv |
| VS-0525-YC152 | Recombinant Anti-PRNP (AA 119-127 x AA 143-149) Biparatopic Antibody, Tandem scFv (mAb 132 x Clone 31C6) | ELISA, IHC, WB | Tandem scFv |
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