Recombinant Anti-Human PRNP VHH Single Domain Antibody (PNBL-026)
CAT#: PNBL-026
Anti-Human PRNP VHH Single Domain Antibody is a recombinant protein produced in E. coli.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_B_7_5.jpg
Normal Tissue
Figure 4 Caudate
Neuronal cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/95554_B_9_7.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_A_9_3.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171867-PRNP
❮
❯
Specifications
- Immunogen
- Human prion protein
- Host Species
- Llama
- Derivation
- Llama
- Type
- Llama VHH
- Species Reactivity
- Human
- Clone
- PNBL-026
- Applications
- This product is suitable for use in WB, ELISA and most other immunological methods.
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
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Reliable Performance
I have used the Recombinant Anti-Human PRNP Single Domain Antibody in several Western blots and it consistently delivers high specificity and minimal background noise. A reliable tool for prion protein research.
Versatile Application
We have successfully used this antibody in ELISA and Western blotting. Its versatility across different techniques is remarkable, making it a cost-effective choice for our lab.
Superior Stability
Compared to other antibodies we've tried, the single domain structure offers superior stability under various experimental conditions. This is especially useful for long-term studies.
Effective with Minor Tweaks
While the antibody is highly effective in Western blot and ELISA, we had to tweak our protocol slightly to get optimal results in other experiments. Overall, a solid choice.
Reliable in Protein Detection
This antibody has proven reliable for detecting prion protein in various applications. We encountered minor issues with non-specific binding in some assays, which were resolved with additional blocking steps.
Q&As
-
How does this antibody contribute to the study of neurodegenerative diseases?
A: This antibody aids in the study of neurodegenerative diseases by enabling the detection and quantification of prion protein aggregates associated with conditions such as Alzheimer's and Parkinson's disease models.
-
What is the main target of this antibody?
A: The primary target of the Recombinant Anti-Human PRNP Single Domain Antibody is the prion protein (PRNP), which is implicated in prion diseases.
-
Are there any known diseases associated with PRNP that this antibody can help study?
A: Yes, PRNP is associated with prion diseases, such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and other transmissible spongiform encephalopathies.
-
What applications can the Recombinant Anti-Human PRNP Single Domain Antibody be used for?
A: This antibody is primarily used in research applications such as Western blotting and ELISA to study PRNP expression and function.
-
Which specific properties make single domain antibodies advantageous?
A: Single-domain antibodies are advantageous due to their small size, high stability, strong binding affinity, and ability to access epitopes that are otherwise inaccessible to conventional antibodies.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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|---|---|---|---|
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| IAB-B034(T) | Recombinant Anti-human PRNP Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-310 | Mouse Anti-PRNP Recombinant Antibody (clone POM2); scFv Fragment | WB, IHC, FuncS | Mouse scFv |
| PSBW-089 | Mouse Anti-PRNP Recombinant Antibody (clone 3F4); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0282CQ-S(P) | Human Anti-PRNP Recombinant Antibody (clone boPrP-15); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0909-FY-F(E) | Mouse Anti-PRNP Recombinant Antibody Fab Fragment (HPAB-0909-FY-F(E)) | WB, ELISA | Mouse Fab |
| PABX-161-S(P) | Mouse Anti-PRNP Recombinant Antibody (clone POM1); scFv Fragment | ELISA, IP, IHC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-089 | Mouse Anti-PRNP Recombinant Antibody (clone 3F4) | ELISA | Mouse IgG2a |
| HPAB-0282CQ | Human Anti-PRNP Recombinant Antibody (clone boPrP-15) | ELISA, WB | Human IgG |
| HPAB-0283CQ | Human Anti-PRNP Recombinant Antibody (clone huPrP-18) | ELISA, WB | Human IgG |
| HPAB-0284CQ | Human Anti-PRNP Recombinant Antibody (clone huPrP-39) | ELISA, WB | Human IgG |
| VS3-FY1851 | Rabbit Anti-PRNP Recombinant Antibody (clone R03-2E2) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-953LC | Anti-Human PRNP Recombinant Antibody (1A1) | FuncS, FC | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-954LC | Anti-Human PRNP Recombinant Antibody (V5B2) | ELISA | Mouse antibody |
| MRO-955LC | Mouse Anti-Prnp Recombinant Antibody (MRO-955LC) | ELISA, WB | Mouse IgG |
| MRO-956LC | Mouse Anti-Prnp Recombinant Antibody (MRO-956LC) | ELISA, WB | Mouse IgG |
| MRO-957LC | Mouse Anti-Prnp Recombinant Antibody (MRO-957LC) | ELISA, WB | Mouse IgG |
| MRO-942LC-S(P) | Anti-Sheep PRNP Recombinant Antibody scFv Fragment (6.1) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-943LC-F(E) | Anti-Mouse Prnp Recombinant Antibody Fab Fragment (D13) | ELISA | Human antibody |
| MRO-944LC-F(E) | Anti-Mouse Prnp Recombinant Antibody Fab Fragment (D18) | ELISA | Human antibody |
| MRO-945LC-F(E) | Anti-Mouse Prnp Recombinant Antibody Fab Fragment (R72) | ELISA | Human antibody |
| MRO-946LC-F(E) | Anti-Mouse Prnp Recombinant Antibody Fab Fragment (R1) | ELISA | Human antibody |
| MRO-947LC-F(E) | Anti-Mouse Prnp Recombinant Antibody Fab Fragment (R2) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0727MZ | Chicken Anti-PRNP Polyclonal IgY | ICC, IF | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2871 | Hi-Affi™ Recombinant Rabbit Anti-PRNP Monoclonal Antibody (DS2871AB) | WB, FC, IHC-P, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0594CQ | Recombinant Mouse Anti-Human PRNP Antibody (ICSM68) | ELISA | IgG |
| EPAF-0595CQ | Recombinant Mouse Anti-Human PRNP Antibody (ICSM39) | ELISA | IgG |
| EPAF-0596CQ | Recombinant Mouse Anti-Human PRNP Antibody (ION6) | ELISA | IgG |
| EPAF-0597CQ | Recombinant Mouse Anti-Human PRNP Antibody (ICSM56) | ELISA | IgG1 |
| EPAF-0598CQ | Recombinant Mouse Anti-Human PRNP Antibody (ICSM72) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0294-CN-F(E) | Human Anti-PRNP Recombinant Antibody (clone D18); Fab Fragment | WB, IF, IHC | Human Fab |
| FAMAB-0295-CN-F(E) | Human Anti-PRNP Recombinant Antibody (clone 3:3); Fab Fragment | WB, IF, IHC | Human Fab |
| FAMAB-0296-CN-F(E) | Human Anti-PRNP Recombinant Antibody (clone 6:4); Fab Fragment | WB, IF, IHC | Human Fab |
| FAMAB-0297-CN-F(E) | Human Anti-PRNP Recombinant Antibody (clone 6:6); Fab Fragment | WB, IF, IHC | Human Fab |
| PFBC-254 | Mouse Anti-PRNP Recombinant Antibody (clone POM6); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY84 | Human Anti-PRNP (clone mAb132) scFv-Fc Chimera | ELISA, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1763 | Anti-PRNP Immunohistochemistry Kit | IHC | |
| VS-0525-XY5727 | Anti-Human PRNP Immunohistochemistry Kit | IHC | |
| VS-0525-XY5728 | Anti-Mouse PRNP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC520 | Recombinant Anti-PRNP Vesicular Antibody, EV Displayed (VS-0425-YC520) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC150 | Recombinant Anti-PRNP (AA 56-90 x AA 83-89) Biparatopic Antibody, Tandem scFv (mAb 106 x mAb 110) | ELISA, IHC, WB | Tandem scFv |
| VS-0525-YC152 | Recombinant Anti-PRNP (AA 119-127 x AA 143-149) Biparatopic Antibody, Tandem scFv (mAb 132 x Clone 31C6) | ELISA, IHC, WB | Tandem scFv |
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