How does this antibody contribute to the study of neurodegenerative diseases?

This antibody aids in the study of neurodegenerative diseases by enabling the detection and quantification of prion protein aggregates associated with conditions such as Alzheimer's and Parkinson's disease models.

What is the main target of this antibody?

The primary target of the Recombinant Anti-Human PRNP Single Domain Antibody is the prion protein (PRNP), which is implicated in prion diseases.

Are there any known diseases associated with PRNP that this antibody can help study?

Yes, PRNP is associated with prion diseases, such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and other transmissible spongiform encephalopathies.

What applications can the Recombinant Anti-Human PRNP Single Domain Antibody be used for?

This antibody is primarily used in research applications such as Western blotting and ELISA to study PRNP expression and function.

Which specific properties make single domain antibodies advantageous?

Single-domain antibodies are advantageous due to their small size, high stability, strong binding affinity, and ability to access epitopes that are otherwise inaccessible to conventional antibodies.

Recombinant Anti-Human PRNP VHH Single Domain Antibody (PNBL-026)

CAT#: PNBL-026

Anti-Human PRNP VHH Single Domain Antibody is a recombinant protein produced in E. coli.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/if_selected.jpg

Subcellular Location Figure 2 IHC staining of human cerebellum

Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/ihc_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuropil
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_B_7_5.jpg

Normal Tissue Figure 4 Caudate

Neuronal cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/95554_B_9_7.jpg

Normal Tissue Figure 5 Colon

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_A_9_3.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171867-PRNP

❮

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Specifications

Immunogen
Human prion protein

Host Species
Llama

Derivation
Llama

Type
Llama VHH

Species Reactivity
Human

Clone
PNBL-026

Applications
This product is suitable for use in WB, ELISA and most other immunological methods.

Product Property

Purity
>95% by SDS-PAGE and HPLC analysis

Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Target

Alternative Names
CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C

Gene ID
5621

UniProt ID
P04156

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Breast cancer biomarkers at key points during disease progression

Reliable Performance

I have used the Recombinant Anti-Human PRNP Single Domain Antibody in several Western blots and it consistently delivers high specificity and minimal background noise. A reliable tool for prion protein research.

Versatile Application

We have successfully used this antibody in ELISA and Western blotting. Its versatility across different techniques is remarkable, making it a cost-effective choice for our lab.

Superior Stability

Compared to other antibodies we've tried, the single domain structure offers superior stability under various experimental conditions. This is especially useful for long-term studies.

Effective with Minor Tweaks

While the antibody is highly effective in Western blot and ELISA, we had to tweak our protocol slightly to get optimal results in other experiments. Overall, a solid choice.

Reliable in Protein Detection

This antibody has proven reliable for detecting prion protein in various applications. We encountered minor issues with non-specific binding in some assays, which were resolved with additional blocking steps.

Q&As

How does this antibody contribute to the study of neurodegenerative diseases?

A: This antibody aids in the study of neurodegenerative diseases by enabling the detection and quantification of prion protein aggregates associated with conditions such as Alzheimer's and Parkinson's disease models.
What is the main target of this antibody?

A: The primary target of the Recombinant Anti-Human PRNP Single Domain Antibody is the prion protein (PRNP), which is implicated in prion diseases.
Are there any known diseases associated with PRNP that this antibody can help study?

A: Yes, PRNP is associated with prion diseases, such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and other transmissible spongiform encephalopathies.
What applications can the Recombinant Anti-Human PRNP Single Domain Antibody be used for?

A: This antibody is primarily used in research applications such as Western blotting and ELISA to study PRNP expression and function.
Which specific properties make single domain antibodies advantageous?

A: Single-domain antibodies are advantageous due to their small size, high stability, strong binding affinity, and ability to access epitopes that are otherwise inaccessible to conventional antibodies.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - PNBL-026.pdf

MSDS

MSDS - PNBL-026.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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