Recombinant Anti-human PRNP Intrabody [(D-Arg)9] (CAT#: IAB-B034(A))

Recombinant anti-PRNP intrabody linked to (D-Arg)9 works within cells to bind PRNP, expressed in CHO cells. Anti-prion intrabodies targeted to the lumen of the endoplasmic reticulum provide a simple and effective means to inhibit the transport of PrPC to the cell surface.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human prion protein
  • Host Species
  • mouse
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Can be useful in applications such as: Immunofluorescence; Flow Cytometry; Western blot; Functional studies

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • PRNP; prion protein; CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; major prion protein; CD230 antigen; prion-related protein

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "PRNP"

Recombinant Antibody

Intrabody

CAT Product Name Application Type
IAB-B034(G) Recombinant Anti-human PRNP Intrabody [+36 GFP] WB, CO-IP, FuncS scFv-(+36GFP)
IAB-B034(T) Recombinant Anti-human PRNP Intrabody [Tat] IF, ELISA, FuncS scFv-Tat

Single-domain Antibody

CAT Product Name Application Type
PNBL-026 Recombinant Anti-Human PRNP VHH Single Domain Antibody (Nb484) WB, ELISA, FuncS Llama VHH

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0727MZ Chicken Anti-PRNP Polyclonal IgY ICC/IF Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2871 Hi-Affi™ Recombinant Rabbit Anti-PRNP Monoclonal Antibody (DS2871AB) WB, FC, IHC-P, ICC/IF IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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