Anti-PRNP Intrabody [(D-Arg)9] (IAB-B034(A))
Recombinant anti-PRNP intrabody linked to (D-Arg)9 works within cells to bind PRNP, expressed in CHO cells. Anti-prion intrabodies targeted to the lumen of the endoplasmic reticulum provide a simple and effective means to inhibit the transport of PrPC to the cell surface.
Specifications
- Immunogen
- human prion protein
- Host
- mouse
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Can be useful in applications such as: Immunofluorescence; Flow Cytometry; Western blot; Functional studies
Target
- Alternative Names
- PRNP; prion protein; CJD; GSS; PrP; ASCR; KURU; PRIP
- Entrez Gene ID
- 5621
- UniProt ID
- P04156
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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