Human Anti-PRNP (clone mAb132) scFv-Fc Chimera (CAT#: VS-0125-FY84)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• mAb132

• Applications
• ELISA, Western Blot

• Related Disease
• Related to prion diseases, such as variant creutzfeldt-Jakob disease

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• CJD, GSS, PrP, ASCR, KURU, PRIP, PrPc, CD230, AltPrP, p27-30, PrP27-30, PrP33-35C

• Gene ID
• 5621

• UniProt ID
• P04156

• Sequence Similarities
• Belongs to the prion family.

• Cellular Localization
• Cell membrane; Lipid-anchor, GPI-anchor
  Golgi apparatus

• Post Translation Modifications
• The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.
  Glycosylation at Thr95, Asn181, Thr193, and Asn197
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect PRIO_HUMAN (2056)
  Glycosylation from GlyGen 4 sites, 12 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)

• Protein Refseq
• NP_000302.1; NP_001073590.1; NP_001073591.1; NP_001073592.1; NP_001258490.1

• Function
• Its primary physiological function is unclear.
  May play a role in neuronal development and synaptic plasticity.
  May be required for neuronal myelin sheath maintenance.
  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.
  May play a role in iron uptake and iron homeostasis.
  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).
  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.
  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

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