Recombinant Anti-PRNP (AA 119-127 x AA 143-149) Biparatopic Antibody, Tandem scFv (mAb 132 x Clone 31C6) (CAT#: VS-0525-YC152)

• Host Animal 1
• Mouse

• Host Animal 2
• Mouse

• Specificity
• Mouse Prion Protein

• Species Reactivity
• Mouse

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• mAb 132

• Clone 2
• 31C6

• Epitope 1
• aa 119-127, AVVGGLGGY

• Epitope 2
• aa 143-149

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, IHC, WB

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Prion protein

• Introduction
• The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.

• Alternative Names
• PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP; AA960666; AI325101; prP27-30; prP33-35C

• Gene ID
• 19122

• UniProt ID
• P04925

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