Anti-Mouse Prnp Recombinant Antibody (6H10)

Name: Anti-Mouse Prnp Recombinant Antibody (6H10)
SKU: MRO-948LC
Rating: 5 (1 reviews)

CAT#: MRO-948LC

This product is a recombinant mouse anti-mouse prion protein monoclonal antibody. 6H10 specifically binds to PrP which is an infectious agent composed entirely of protein material and can be potentially used in the diagnosis and treatment of transmissible spongiform encephalopathies.

Published Data Gene Expression

ELISA

Figure 1 The reactivities between abnormal type prion protein treated with various concentrations of proteinase K monoclonal antibodies.

ELISA

Figure 2 The reactivities between abnormal type prion protein treated with various concentrations of guanidine hydrochloride after treatment with proteinase K monoclonal antibodies.

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/if_selected.jpg

Subcellular Location Figure 2 IHC staining of human cerebellum

Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/ihc_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuropil
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_B_7_5.jpg

Normal Tissue Figure 4 Caudate

Neuronal cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43398/95554_B_9_7.jpg

Normal Tissue Figure 5 Colon

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42754/95550_A_9_3.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171867-PRNP

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Specifications

Host Species
Mouse

Type
Mouse antibody

Specificity
Mouse

Clone
6H10

Applications
ELISA

Related Disease
Transmissible spongiform encephalopathies

Applications

Application Notes
This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay.

Target

Alternative Names
PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP; AA960666; AI325101; prP27-30; prP33-35C; prion protein; Prnp

Gene ID
19122

UniProt ID
P04925

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - MRO-948LC.pdf

MSDS

MSDS - MRO-948LC.pdf

COA

Certificate of Analysis Lookup

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