Recombinant Rabbit Anti-SNCA Capture Antibody (clone R85-8W-7)
CAT#: VS3-WK1796
This antibody is a rabbit recombinant antibody against human SNCA. It was developed by immunization of rabbit with recombinant human SNCA protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R85-8W-7 and R55-3F-1. The clone R85-8W-7 can be used as a capture antibody in ELISA analysis to identify human SNCA.
Gene Expression
Normal Tissue
Figure 1 High expression in cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
Normal Tissue
Figure 5 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
❮
❯
Specifications
- Immunogen
- Recombinant human SNCA protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SNCA
- Species Reactivity
- Human
- Clone
- R85-8W-7
- Applications
- ELISA
- Conjugate
- Unconjugated
- Related Disease
- Parkinson's disease (PD); Dementia with Lewy bodies (DLB); Multiple system atrophy (MSA)
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Synuclein Alpha; Synuclein, Alpha (Non A4 Component Of Amyloid Precursor); Alpha-Synuclein; PARK1; NACP; Parkinson Disease (Autosomal Dominant, Lewy Body) 4; Non A4 Component Of Amyloid Precursor; Non-A4 Component Of Amyloid Precursor
- Gene ID
- 6622
- UniProt ID
- P37840
- Long Name
- Synuclein Alpha
- Sequence Similarities
- Belongs to the synuclein family.
- Cellular Localization
- Cytoplasm; Membrane; Nucleus; Synapse; Secreted; Cell projection
- Post Translation Modifications
- Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.
Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.
Ubiquitinated. The predominant conjugate is the diubiquitinated form.
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
- Protein Refseq
- NP_000336.1; NP_001139526.1; NP_001139527.1
- Function
- Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.
Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Detection antibody
Isotype Control
- CAT
- Product Name
Secondary Antibody
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B031(A) | Recombinant Anti-human SNCA Intrabody [(D-Arg)9] | FC, IF, FuncS | scFv-(D-Arg)9 |
| IAB-B031(G) | Recombinant Anti-human SNCA Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B031(T) | Recombinant Anti-human SNCA Intrabody [Tat] | ELISA, IF, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-086 | Recombinant Anti-SNCA VHH Single Domain Antibody (PNBL-086) | WB, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0740CLV | Rabbit Anti-SNCA Recombinant Antibody (TAB-0740CLV) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-F(E) | Rabbit Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0740CLV-F(E)) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-S(P) | Rabbit Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0740CLV-S(P)) | ELISA | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0741CLV | Mouse Anti-SNCA Recombinant Antibody (TAB-0741CLV) | IF | Mouse IgG1 |
| TAB-0742CLV | Mouse Anti-SNCA Recombinant Antibody (TAB-0742CLV) | ELISA, ICC, FuncS, IHC, Block | Mouse IgG2a |
| TAB-0743CLV | Mouse Anti-SNCA Recombinant Antibody (TAB-0743CLV) | ELISA | Mouse IgG2a |
| TAB-0744CLV | Mouse Anti-SNCA Recombinant Antibody (TAB-0744CLV) | ELISA | Mouse IgG1 |
| TAB-0745CLV | Mouse Anti-SNCA Recombinant Antibody (TAB-0745CLV) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1977CQ | Recombinant Human Anti-SNCA Antibody (NAC32) | IHC, WB, BL | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0154 | Hi-Affi™ Recombinant Rabbit Anti-alpha + beta Synuclein Monoclonal Antibody (DS154AB) | FC, WB, ICC, IF | IgG |
| MOR-3354 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (DS3354AB) | IHC, ICC, FC, IP | IgG |
| MOR-4530 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (TH38DS) | WB, IF, ICC, IHC-P, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN | Mouse Anti-SNCA Recombinant Antibody (NS-005CN) | WB, ELISA, FC | Mouse IgG2a |
| NS-088CN | Mouse Anti-SNCA Recombinant Antibody (NS-088CN) | WB, ELISA, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (NS-005CN-F(E)) | WB, ELISA, FC | Mouse Fab |
| HPAB-653-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-653-FY-F(E)) | WB, IP, ELISA | Mouse Fab |
| HPAB-654-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-654-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-M0696-YC-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-M0696-YC-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-0753-WJ-F(E) | Human Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-0753-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-005CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| NS-088CN-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (NS-088CN-S(P)) | WB, ELISA, IHC | Mouse scFv |
| FAMAB-0260-CN-S(P) | Human Anti-SNCA Recombinant Antibody (clone D10); scFv Fragment | ELISA | Human scFv |
| FAMAB-0261-CN-S(P) | Human Anti-SNCA Recombinant Antibody (clone 6E); scFv Fragment | ELISA | Human scFv |
| HPAB-0753-WJ-S(P) | Human Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-0753-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY244 | AbPlus™ Anti-SNCA Magnetic Beads (JB42-33) | IP, Protein Purification | |
| VS-0724-YC791 | AbPlus™ Anti-SNCA Magnetic Beads (VS-0724-YC791) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY32 | Human Anti-SNCA scFv-Fc Chimera (VS-0325-FY32) | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2129 | Anti-SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6773 | Anti-Mouse SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6772 | Anti-Human SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6774 | Anti-Rat SNCA Immunohistochemistry Kit | IHC |
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