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    For Research Use Only. Not For Clinical Use.


    Background

    EGFRvIII is a constitutively active, ligand-independent mutant of epidermal growth factor receptor (EGFR), arising from the in-frame deletion of exons 2-7 in the EGFR gene. This deletion eliminates the extracellular ligand-binding domain, triggering spontaneous dimerization and persistent activation of oncogenic signaling pathways (e.g., RAS/RAF/MEK/ERK, PI3K/AKT/mTOR) that drive cell proliferation, survival and metastasis. Uniquely absent in normal tissues but abundant in multiple malignancies (e.g., glioblastoma, non-small cell lung cancer), EGFRvIII serves as a highly attractive target for cancer diagnosis and targeted therapy.
    In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
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