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    EGFRvIII & CD3

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    Anti-EGFRvIII & CD3 Products

    • TRX4 (Gly-002CL)
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    For Research Use Only. Not For Clinical Use.


    Background

    The class III variant of the EGFR (EGFRvIII) is the most frequently found EGFR variant in glioblastoma. EGFRvIII is characterized by a deletion of exons 2-7 of the EGFR gene, resulting in an in-frame deletion of 801 base pairs of the coding region, i.e., deletion of 6-273 amino acid residues (based on the residue numbers of mature EGFR), as well as the generation of a new glycine at the fusion junction. EGFRvIII has been shown to have a ligand-independent, weak but constitutively active kinase activity as well as enhanced tumorigenicity. In addition to gliomas, EGFRvIII has been detected in ductal and intraductal breast carcinoma, non-small cell lung carcinomas, ovarian carcinomas, prostate TME-targeting Antibody, and squamous cell carcinoma of the head and neck.
    CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
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