Human Anti-F8 Recombinant Antibody (clone MH8) (CAT#: FAMAB-0037JF)
Recombinant monoclonal antibody can specially bind to human factor VIII. This human anti-F8 antibody MH8 can possibly be made use of to block the uptake of patients antibodies on therapeutic factor VIII.
Specific Inquiry
WB
Figure 1 WB analysis of purified muTNFR-Fc.
M, molecular weight marker; NR, nonreducing conditions; R, reducing conditions.
Doll, F., Schwager, K., Hemmerle, T., & Neri, D. (2013). Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse. Arthritis research & therapy, 15(5), R138.
Inhib
Figure 2 muTNFR-Fc inhibited tumor necrosis factor (TNF)-induced killing of mouse fibroblasts.
Mean ± standard deviation, n = 3.
Doll, F., Schwager, K., Hemmerle, T., & Neri, D. (2013). Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse. Arthritis research & therapy, 15(5), R138.
FuncS
Figure 3 Therapy studies in mice with collagen-induced arthritis.
Fifteen of 50 mice (30%) developed an explosive disease and could not be included in the therapy.
Doll, F., Schwager, K., Hemmerle, T., & Neri, D. (2013). Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse. Arthritis research & therapy, 15(5), R138.
IHC
Figure 4 Immunohistochemical staining of human endometriotic tissue.
Immunohistochemistry with the F8 was conducted.
Schwager, K., Bootz, F., Imesch, P., Kaspar, M., Trachsel, E., & Neri, D. (2011). The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model. Human reproduction, 26(9), 2344-2352.
IF
Figure 5 Immunofluorescence staining of human endometriotic tissue. Immunohistochemistry with the SIPs L19, F16 and F8 was conducted.
Immunofluorescence with the F8 was conducted.
Schwager, K., Bootz, F., Imesch, P., Kaspar, M., Trachsel, E., & Neri, D. (2011). The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model. Human reproduction, 26(9), 2344-2352.
Specifications
- Immunogen
- Recombinant factor VIII
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- Human factor VIII
- Species Reactivity
- Human
- Clone
- MH8
- Applications
- WB, IF, IHC, Inhib, FuncS
- Related Disease
- Hemophilia A
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The F8 antibody has been reported in applications of Western Blot, Immunofluorescence, Immunohistochemistry, Functional Assay, Inhibition.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-930-VHH | Recombinant Anti-Human F8 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-259CL | Human Anti-F8 Recombinant Antibody (TAB-259CL) | ELISA | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-051 | Mouse Anti-F8 Recombinant Antibody (clone 3E6); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| PFBL-052 | Mouse Anti-F8 Recombinant Antibody (clone G99); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| FAMAB-0037JF-F(E) | Human Anti-F8 Recombinant Antibody (clone MH8); Fab Fragment | IP, ELISA, FuncS | Human Fab |
| FAMAB-0038JF-F(E) | Human Anti-F8 Recombinant Antibody (clone DH10); Fab Fragment | IP, ELISA, FuncS | Human Fab |
| FAMAB-0039JF-F(E) | Human Anti-F8 Recombinant Antibody (clone JM4); Fab Fragment | IP, ELISA, FuncS | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-016WM | Anti-Human F8 Recombinant Antibody (BOIIB2) | Inhib, ELISA | |
| TAB-017WM | Anti-Human F8 Recombinant Antibody (4F50) | ELISA | |
| TAB-016WM-S(P) | Anti-Human F8 Recombinant Antibody scFv Fragment (BOIIB2) | ELISA | |
| TAB-017WM-S(P) | Anti-Human F8 Recombinant Antibody scFv Fragment (4F50) | ELISA | |
| TAB-016WM-F(E) | Anti-Human F8 Recombinant Antibody Fab Fragment (BOIIB2) | ELISA |
Fab Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-014LC | Recombinant Anti-Human F8 Antibody (Fab glycosylation) | ELISA | Human antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-015LC | Recombinant Anti-Human F8 Antibody (Non-glycosylated) | ELISA | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1608MZ | Recombinant Mouse Anti-Human F8 Antibody (clone 023) | ELISA, WB | Mouse antibody |
| FAMAB-0197-CN | Human Anti-F8 Recombinant Antibody (clone KM33) | WB | Human IgG |
| HPAB-0178CQ | Mouse Anti-F8 Recombinant Antibody (HPAB-0178CQ) | ELISA, DB, Inhib | Mouse IgG2b, κ |
| HPAB-1977-FY | Human Anti-F8 Recombinant Antibody (clone 92-137) | Inhib | Human IgG |
| HPAB-1978-FY | Human Anti-F8 Recombinant Antibody (clone 92-102) | Inhib | Human IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-058 | Recombinant Human Anti-F8 Antibody (BO2C11) | WB, ELISA, FuncS, Inhib, PK, IP, SPR | IgG |
| PABX-058-S (P) | Recombinant Human Anti-F8 Antibody scFv Fragment (BO2C11) | WB, ELISA, FuncS | scFv |
| PABX-058-F (E) | Recombinant Human Anti-F8 Antibody Fab Fragment (BO2C11) | WB, ELISA, FuncS | Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-765CQ | Mouse Anti-F8 Recombinant Antibody (clone CBL215) | ELISA, WB, Neut | Mouse IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1229 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone DS1229AB) | ELISA | Rabbit IgG |
| MOR-4166 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI243DS) | ELISA | Rabbit IgG |
| MOR-4167 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI244DS) | ELISA | Rabbit IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0611LC | Human Anti-F8 Recombinant Antibody (clone BO2C11) | ELISA | Human IgG4 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0096-YC-S(P) | Human Anti-F8 Recombinant Antibody (clone YK3.3.38); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0197-CN-S(P) | Human Anti-F8 Recombinant Antibody (clone KM33); scFv Fragment | WB | Human scFv |
| FAMAB-0286JF-S(P) | Human Anti-F8 Recombinant Antibody (clone VK34); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0287JF-S(P) | Human Anti-F8 Recombinant Antibody (clone VK41); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-1613WJ-S(P) | Human Anti-F8 Recombinant Antibody; scFv Fragment (clone KRIX 1) | ELISA, IP | Human scFv |
MHC Tetramer for Other Applications
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF075 | DRB1*11:01/Factor VIII Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Monomer | MHC Multimer |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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