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    KRT5

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
    Protein class

    Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Basal squamous epithelial cells, Basal prostatic cells)

    Immune cell specificity

    Immune cell enriched (plasmacytoid DC)

    Cell line specificity

    Group enriched (HaCaT, HBEC3-KT, hTCEpi)

    Interaction

    Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network (PubMed:28899683). Heterodimer with KRT14 (PubMed:22705788). Interacts with TCHP (PubMed:15731013). Interacts with EPPK1 (By similarity).

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