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    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

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    For Research Use Only. Not For Clinical Use.


    Background

    CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.
    Human CD133 is a penta-span transmembrane glycoprotein. It is a marker of neural, endothelial and hematopoietic stem cells. Its expression is also seen in cancer initiating cells in many tumors including that of brain, prostrate, colon and breast and is, therefore, used widely as a molecular marker to isolate and characterize these cell phenotypes. Targeting CD133 may also enable enhanced delivery of cytotoxic therapies to cancer initiating cells. Further development of CD133 as a diagnostic marker
    and/or therapeutic target, requires highly sensitive reagents that exclusively recognize CD133.
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