10-FnIII scaffold protein anti-Human KDR (CAT#: SFN-L012)

The tenth fibronectin type III domain (10Fn3) that bound KDR was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=60 pM) for KDR as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • 10-FnIII
  • Origin
  • Fibronectin
  • Core Structure
  • β-sandwich of 7 β-strands
  • Variable Regions
  • 2–3 Loops
  • Target
  • KDR
  • Species Reactivity
  • Human
  • Expression Host
  • BL21 (DE3) cells
  • Affinity Constant
  • 60 pM
  • Applications
  • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

  • Alternative Names
  • Fibronectin; 10-FnIII; FLK1; CD309; VEGFR; VEGFR2

Downloads

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Intrabody

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IAB-B066(G) Recombinant Anti-human KDR Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
IAB-B066(T) Recombinant Anti-human KDR Intrabody [Tat] IF, ELISA, FuncS scFv-Tat

Humanized Antibody

CAT Product Name Application Type
TAB-202 Humanized Anti-KDR Recombinant Antibody (clone Alacizumab); di - Fab' Fragment IF, IP, Neut, FuncS, ELISA, FC, ICC Humanized (from mouse) di - Fab'
TAB-411CQ Anti-Human KDR Recombinant Antibody (HLX06) ELISA Humanized antibody
TAB-411CQ-S(P) Anti-Human KDR Recombinant Antibody scFv Fragment (HLX06) ELISA Humanized antibody
TAB-411CQ-F(E) Anti-Human KDR Recombinant Antibody Fab Fragment (HLX06) ELISA Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G047E Anti-KDR immunotoxin (IgG1)-PE Cytotoxicity assay, Function study

Recombinant Antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0624MZ Chicken Anti-VEGFR-2 Polyclonal IgY IHC, WB Chicken antibody
BRD-0709MZ Chicken Anti-KDR Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-079 Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

Single-domain Antibody

CAT Product Name Application Type
HPAB-0298-YJ-VHH Recombinant Human Anti-KDR Nano Antibody (NTV1) Inhib Human VHH

MHC Tetramer for Cancer

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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