Anti-CD37 (K7153A)-SMCC-DM1 ADC (IMGN529) (CAT#: ADC-L019)

• Antibody Overview
• Murine/human chimeric CD37-specific monoclonal IgG1k antibody mirvetuximab

• Clone
• K7153A

• Antibody Conjugation
• Chimeric murine/human

• Linker
• SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)

• Linker Class/Description
• Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.

• Alternative Names
• GP52-40; TSPAN26

• Gene ID
• 951

• UniProt ID
• P11049

• ADC-064LCT
• Anti-CD37 (K7153A)-SMCC-DM1 ADC

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