anti-CD86 immunotoxin 1G10 (IgG)-Gel (CAT#: AGTO-L002G)

This immunotoxin was achieved by conjugating/fusing the anti-CD86 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD86-expressing cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of Hodgkin's disease or other CD86-expressing tumours.


Specific Inquiry
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  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Rat
  • Species Reactivity
  • Mouse
  • Clone
  • 1G10
  • Molecule Class
  • L kappa; IgG2a-Gel
  • Toxin Description
  • Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Hodgkin's lymphoma

Target

  • Alternative Names
  • CD86; CD86 molecule; B70; B7-2; B7.2; LAB72; CD28LG2; T-lymphocyte activation antigen CD86; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); Hodgkin's lymphoma; Gelonin; Gel

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone 1G10"

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Immunotoxin

CAT Product Name Application Type
AGTO-L002S anti-CD86 immunotoxin 1G10 (IgG)-Sap Cytotoxicity assay, Functional assay
AGTO-L002O anti-CD86 immunotoxin 1G10 (IgG)-Bouganin Cytotoxicity assay, Functional assay

Chimeric Antibody

CAT Product Name Application Type
TAB-361LC Anti-Human CD86 Recombinant Antibody (chFun1) IHC Chimeric antibody (mouse/human)
TAB-361LC-S(P) Anti-Human CD86 Recombinant Antibody scFv Fragment (chFun1) IHC Chimeric antibody (mouse/human)
TAB-361LC-F(E) Anti-Human CD86 Recombinant Antibody Fab Fragment (chFun1) IHC Chimeric antibody (mouse/human)

Neutralizing Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-423CQ Rat Anti-Cd86 Recombinant Antibody (clone 2D10), Biotin FC, IHC-Fr, IP, Block Rat IgG2b, κ
NEUT-424CQ Rat Anti-Cd86 Recombinant Antibody (clone GL-1) FC, Block, IF, IHC, IP Rat IgG2a, κ
NEUT-425CQ Rat Anti-Cd86 Recombinant Antibody (clone MAB0827) Block, FC, IHC-Fr, IP Rat IgG2

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0588 Hi-Affi™ Rabbit Anti-CD86 Recombinant Antibody (clone DS588AB) WB, FC, IHC Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-1586WJ-F(E) Mouse Anti-CD86 Recombinant Antibody; Fab Fragment (clone 3D1) ELISA, WB Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-1586WJ-S(P) Mouse Anti-CD86 Recombinant Antibody; scFv Fragment (clone 3D1) ELISA, WB Mouse scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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