1 0
Cart
    Inquiry
    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
    + Filter
    Loading...
    Custom Services order now ship next day

    CD86

    Loading...

    Anti-CD86 Products

    View More Products

    Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

    More Infomation

    Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
    Protein class

    CD markers, FDA approved drug targets

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (monocytes, Macrophages, Langerhans cells, Hofbauer cells, Kupffer cells, Microglial cells)

    Immune cell specificity

    Group enriched (non-classical monocyte, classical monocyte, intermediate monocyte, myeloid DC, memory B-cell, naive B-cell)

    Cell line specificity

    Cell line enriched (HDLM-2)

    Interaction

    Homodimer. Interacts with MARCH8. Interacts (via cytoplasmic domain) with PHB1 and PHB2; the interactions increases after priming with CD40 (By similarity). (Microbial infection) Interacts with adenovirus subgroup b fiber protein.

    Molecular function

    Host cell receptor for virus entry, Receptor

    More Types Infomation
    Related Diseases
    Rheumatoid Arthritis Rheumatoid Arthritis
    Systemic Lupus Erythematosus Systemic Lupus Erythematosus
    Allograft Rejection Allograft Rejection
    Autoimmune Thyroid Disease Autoimmune Thyroid Disease
    Graft-versus-Host Disease Graft-versus-Host Disease
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young
    Go to compare

    Go to compare

    Merry Christmas & Happy New Year
    Happy Thanksgiving close ad