Anti-Human DLL4 Recombinant Antibody (TAB-204)

Name: Anti-Human DLL4 Recombinant Antibody (TAB-204)
SKU: TAB-204
Rating: 5 (1 reviews)

CAT#: TAB-204

Recombinant monoclonal antibody to DLL4. It is a humanized monoclonal antibody designed for the treatment of cancer.

Gene Expression

Normal Tissue Figure 1 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg

Normal Tissue Figure 2 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (BJ hTERT+, HUVEC TERT2, SCLC-21H)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4

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Specifications

Immunogen
Partial recombinant DLL4 ragment.

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG2 - kappa

Specificity
Tested positive against native human antigen.

Species Reactivity
Human

Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.

MW
145.3 kDa

Related Disease
Cancers

Product Property

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Target

Alternative Names
Demcizumab;1243262-17-0;OMP-21M18;DLL4;delta-like 4 (Drosophila);delta like 4 homolog (Drosophila);delta-like protein 4;delta4;delta 4;delta ligand 4;notch ligand DLL4;delta-like 4 homolog;delta-like 4 protein;notch ligand delta-2;drosophila Delta homolog

Gene ID
54567

UniProt ID
Q9NR61

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(Creative Biolabs Cat# TAB-204, RRID: AB_3111872)

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Biosimilar Overview

Please refer to Demcizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Demcizumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-204.pdf

MSDS

MSDS - TAB-204.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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CAT	Product Name	Application	Type
TAB-217MZ	Human Anti-DLL4 Recombinant Antibody (TAB-217MZ)	FC, FuncS	Chimeric (mouse/human) IgG
TAB-217MZ-S(P)	Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-217MZ-S(P))	FC	Mouse scFv
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CAT	Product Name	Application	Type
TAB-216MZ-S(P)	Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-216MZ-S(P))	FC	Mouse scFv
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TAB-232MZ-S(P)	Rat Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-232MZ-S(P))	ELISA, FC	Rat scFv
TAB-233MZ-S(P)	Rat Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-233MZ-S(P))	ELISA, FC	Rat scFv
TAB-234MZ-S(P)	Rat Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-234MZ-S(P))	ELISA, FC	Rat scFv

CAT	Product Name	Application	Type
TAB-218MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-218MZ-S(P))	ELISA, FC	Human scFv
TAB-219MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-219MZ-S(P))	ELISA, FC	Human scFv
TAB-220MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-220MZ-S(P))	ELISA, FC	Human scFv
TAB-221MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-221MZ-S(P))	ELISA, FC	Human scFv
TAB-222MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-222MZ-S(P))	FC	Human scFv

CAT	Product Name	Application	Type
NEUT-707CQ	Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-2)	Block	Hamster IgG

CAT	Product Name	Application	Type
MOR-4140	Hi-Affi™ Rabbit Anti-DLL4 Recombinant Antibody (clone SI213DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0203-CN	Human Anti-DLL4 Recombinant Antibody (HPAB-0203-CN)	ELISA, WB, FC, IP	Human IgG1
HPAB-0204-CN	Human Anti-DLL4 Recombinant Antibody (HPAB-0204-CN)	ELISA, WB, FC, IP	Human IgG1
HPAB-0205-CN	Human Anti-DLL4 Recombinant Antibody (HPAB-0205-CN)	ELISA, WB, FC, IP	Human IgG4
HPAB-0206-CN	Mouse Anti-DLL4 Recombinant Antibody (HPAB-0206-CN)	ELISA, WB, FC, IHC, IF, ICC	Mouse IgG2
HPAB-0208-CN	Human Anti-DLL4 Recombinant Antibody (HPAB-0208-CN)	ELISA, WB, FC, IHC, IF, ICC	Humanized IgG2

CAT	Product Name	Application	Type
HPAB-0075-CN-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0075-CN-S(P))	ELISA, WB, FC	Human scFv
HPAB-0076-CN-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0076-CN-S(P))	ELISA, WB, FC	Human scFv
HPAB-0203-CN-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0203-CN-S(P))	ELISA, WB, FC, IP	Human scFv
HPAB-0204-CN-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0204-CN-S(P))	ELISA, WB, FC, IP	Human scFv
HPAB-0205-CN-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0205-CN-S(P))	ELISA, WB, FC, IP	Human scFv

CAT	Product Name	Application	Type
HPAB-0075-CN-F(E)	Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0075-CN-F(E))	ELISA, WB, FC	Human Fab
HPAB-0076-CN-F(E)	Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0076-CN-F(E))	ELISA, WB, FC	Human Fab
HPAB-0152-LSX-F(E)	Mouse Anti-DLL4 Recombinant Antibody (clone 21H3); Fab Fragment	ELISA, FC	Mouse Fab
HPAB-0154-LSX-F(E)	Mouse Anti-DLL4 Recombinant Antibody (clone 9G8); Fab Fragment	ELISA, FC	Mouse Fab
HPAB-0155-LSX-F(E)	Mouse Anti-DLL4 Recombinant Antibody (clone 2H10); Fab Fragment	ELISA, FC	Mouse Fab

CAT	Product Name	Application	Type
AFC-TAB-204	Afuco™ Anti-DLL4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-204)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-1512-FY	Recombinant Llama Anti-DLL4 Single Domain Antibody (HPAB-1512-FY)	Block, ELISA, FC	Llama VHH
HPAB-1513-FY	Recombinant Llama Anti-DLL4 Single Domain Antibody (HPAB-1513-FY)	Block, ELISA, FC	Llama VHH
HPAB-1514-FY	Recombinant Llama Anti-DLL4 Single Domain Antibody (HPAB-1514-FY)	Block, ELISA, FC	Llama VHH

CAT	Product Name	Application	Type
VS-0424-XY79	AbPlus™ Anti-DLL4 Magnetic Beads (VS-0424-XY79)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0425-FY100	Human Anti-DLL4 (clone 21H3RK) scFv-Fc Chimera	FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC215	Recombinant Anti-DLL4 Vesicular Antibody, EV Displayed (VS-0425-YC215)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY2018	Anti-DLL4 Immunohistochemistry Kit	IHC

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