Afuco™ Anti-DLL4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-204)

Name: Afuco™ Anti-DLL4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-204)
SKU: AFC-TAB-204
Rating: 5 (1 reviews)

CAT#: AFC-TAB-204

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to DLL4. It is a humanized monoclonal antibody designed for the treatment of cancer.

Gene Expression

Normal Tissue Figure 1 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg

Normal Tissue Figure 2 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (BJ hTERT+, HUVEC TERT2, SCLC-21H)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4

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Specifications

Immunogen
Partial recombinant DLL4 ragment.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
ELISA, FC, IP, FuncS, IF, Neut

Conjugate
Unconjugated

Generic Name
Demcizumab

Related Disease
Cancers

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
DLL4; delta-like 4 (Drosophila); delta like 4 homolog (Drosophila); delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2;

Gene ID
54567

UniProt ID
Q9NR61

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Biosimilar Overview

Please refer to Demcizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Demcizumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-204.pdf

MSDS

MSDS - AFC-TAB-204.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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DrugMonitor™ Anti-Demcizumab Antibody (VS-1224-YC348)
Demcizumab is in clinical investigation for treating nonsquamous non-small cell lung cancer. The DrugMonitor™ Anti-Demcizumab Antibody (VS-1224-YC348) is an anti-drug antibody (ADA) against Demcizumab. This drug-based antibody is raised in mice immunized with the Demcizumab. The anti-Demcizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Demcizumab in samples.

See other products for "DLL4"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-204	Anti-Human DLL4 Recombinant Antibody (TAB-204)	ELISA, FC, IP, FuncS, IF, Neut, WB	IgG2 - kappa

CAT	Product Name	Application	Type
TAB-217CL	Human Anti-DLL4 Recombinant Antibody (TAB-217CL)	WB, IHC, IF, FC, Inhib	Human IgG

CAT	Product Name	Application	Type
TAB-217MZ	Human Anti-DLL4 Recombinant Antibody (TAB-217MZ)	FC, FuncS	Chimeric (mouse/human) IgG
TAB-217MZ-S(P)	Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-217MZ-S(P))	FC	Mouse scFv
TAB-217MZ-F(E)	Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-217MZ-F(E))	FC	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-216MZ-S(P)	Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-216MZ-S(P))	FC	Mouse scFv
TAB-227MZ-S(P)	Anti-Human DLL4 Recombinant Antibody scFv Fragment (1C1)	ELISA, FC
TAB-232MZ-S(P)	Rat Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-232MZ-S(P))	ELISA, FC	Rat scFv
TAB-233MZ-S(P)	Rat Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-233MZ-S(P))	ELISA, FC	Rat scFv
TAB-234MZ-S(P)	Rat Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-234MZ-S(P))	ELISA, FC	Rat scFv

CAT	Product Name	Application	Type
TAB-218MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-218MZ-S(P))	ELISA, FC	Human scFv
TAB-219MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-219MZ-S(P))	ELISA, FC	Human scFv
TAB-220MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-220MZ-S(P))	ELISA, FC	Human scFv
TAB-221MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-221MZ-S(P))	ELISA, FC	Human scFv
TAB-222MZ-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-222MZ-S(P))	FC	Human scFv

CAT	Product Name	Application	Type
NEUT-707CQ	Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-2)	Block	Hamster IgG

CAT	Product Name	Application	Type
MOR-4140	Hi-Affi™ Rabbit Anti-DLL4 Recombinant Antibody (clone SI213DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0203-CN	Human Anti-DLL4 Recombinant Antibody (HPAB-0203-CN)	ELISA, WB, FC, IP	Human IgG1
HPAB-0204-CN	Human Anti-DLL4 Recombinant Antibody (HPAB-0204-CN)	ELISA, WB, FC, IP	Human IgG1
HPAB-0142-FY	Human Anti-DLL4 Recombinant Antibody (HPAB-0142-FY)	ELISA	Human IgG
MRO-1817-CN	Rabbit Anti-DLL4 Polyclonal Antibody (MRO-1817-CN)	WB, IF, IHC, FC	Rabbit IgG
MRO-1818-CN	Rabbit Anti-DLL4 Polyclonal Antibody (MRO-1818-CN)	WB, IF, IHC, FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0203-CN-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0203-CN-S(P))	ELISA, WB, FC, IP	Human scFv
HPAB-0204-CN-S(P)	Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0204-CN-S(P))	ELISA, WB, FC, IP	Human scFv
HPAB-0211-WJ-S(P)	Mouse Anti-DLL4 Recombinant Antibody (clone MMGZ01); scFv Fragment	ELISA	Mouse scFv
HPAB-1108-FY-F(E)	Human Anti-DLL4 Recombinant Antibody (clone 61B); scFv Fragment	ELISA	Human scFv
HPAB-1109-FY-F(E)	Human Anti-DLL4 Recombinant Antibody (clone 2-6); scFv Fragment	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-0203-CN-F(E)	Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0203-CN-F(E))	ELISA, WB, FC, IP	Human Fab
HPAB-0204-CN-F(E)	Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0204-CN-F(E))	ELISA, WB, FC, IP	Human Fab
HPAB-0205-CN-F(E)	Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0205-CN-F(E))	ELISA, WB, FC, IP	Human Fab
HPAB-0206-CN-F(E)	Mouse Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0206-CN-F(E))	ELISA, WB, FC, IHC, IF, ICC	Mouse Fab
HPAB-0208-CN-F(E)	Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0208-CN-F(E))	ELISA, WB, FC, IHC, IF, ICC	Humanized Fab

CAT	Product Name	Application	Type
HPAB-1512-FY	Recombinant Llama Anti-DLL4 Single Domain Antibody (HPAB-1512-FY)	Block, ELISA, FC	Llama VHH
HPAB-1513-FY	Recombinant Llama Anti-DLL4 Single Domain Antibody (HPAB-1513-FY)	Block, ELISA, FC	Llama VHH
HPAB-1514-FY	Recombinant Llama Anti-DLL4 Single Domain Antibody (HPAB-1514-FY)	Block, ELISA, FC	Llama VHH

CAT	Product Name	Application	Type
VS-0424-XY79	AbPlus™ Anti-DLL4 Magnetic Beads (VS-0424-XY79)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0425-FY100	Human Anti-DLL4 (clone 21H3RK) scFv-Fc Chimera	FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC215	Recombinant Anti-DLL4 Vesicular Antibody, EV Displayed (VS-0425-YC215)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY2018	Anti-DLL4 Immunohistochemistry Kit	IHC

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