What is the specific clone name and its potential applications?

The clone ID for this antibody is 12.08. It is a human monoclonal antibody that has been validated for use in Enzyme-linked Immunosorbent Assay (ELISA) and Flow Cytometry (FC). It is useful for research into modulating T cell activation and cytokine production.

Is this antibody a specific isotype of IgG?

Yes, this recombinant antibody is a Human IgG2 isotype. It is expressed in CHO cells and is provided as a purified product. It binds specifically to human DLL4 (Delta-like ligand 4) and is suitable for various engineered antibody applications.

Anti-Human DLL4 Recombinant Antibody (12.08)

CAT#: TAB-229MZ

This antibody (12.08) binds to human DLL4. Clone 12.08 is useful for modulating human T cell activation, cytokine production and differentiation. It can be potentially used for scientific research of treating diseases or disorders in humans, including Th17 cell-mediated diseases or disorders.

Gene Expression

Normal Tissue Figure 1 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg

Normal Tissue Figure 2 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (BJ hTERT+, HUVEC TERT2, SCLC-21H)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4

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Specifications

Immunogen
Biotinylated DLL4

Host Species
Human

Derivation
Phage display library

Type
Human antibody

Antibody Isotype
IgG2

Specificity
Human

Clone
12.08

Applications
Enzyme-linked Immunosorbent Assay, Flow Cytometry

Related Disease
A tumor, a cancer, a cell proliferative disorder, a pathological condition associated with angiogenesis or non-neoplastic disorder

Target

Alternative Names
DLL4; delta-like 4 (Drosophila); hdelta2; delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4

Gene ID
54567

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Breast cancer biomarkers at key points during disease progression

Excellent Flow Cytometry Reagent

We used the clone 12.08 antibody for flow cytometry analysis of human cells expressing DLL4. The signal-to-noise ratio was impressive, allowing us to clearly distinguish the population of interest. It is a high-quality reagent for characterizing surface expression of this Notch ligand.

Useful For T Cell Studies

Our lab investigates T cell activation, and this antibody was helpful in modulating cytokine production in our in vitro models. It binds effectively to human DLL4 and works well for research into Th17 cell-mediated mechanisms as suggested in the product description.

Q&As

What is the specific clone name and its potential applications?

A: The clone ID for this antibody is 12.08. It is a human monoclonal antibody that has been validated for use in Enzyme-linked Immunosorbent Assay (ELISA) and Flow Cytometry (FC). It is useful for research into modulating T cell activation and cytokine production.
Is this antibody a specific isotype of IgG?

A: Yes, this recombinant antibody is a Human IgG2 isotype. It is expressed in CHO cells and is provided as a purified product. It binds specifically to human DLL4 (Delta-like ligand 4) and is suitable for various engineered antibody applications.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-229MZ.pdf

MSDS

MSDS - TAB-229MZ.pdf

COA

Certificate of Analysis Lookup

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