Human Anti-FAP Recombinant Antibody; Fab Fragment (TAB-024WM-F(E))

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Citations

1. Sitia, Leopoldo, et al. "Selective targeting of cancer-associated fibroblasts by engineered H-ferritin nanocages loaded with navitoclax." Cells 10.2 (2021): 328. https://doi.org/10.3390/cells10020328
   This research investigates the development of engineered H-Ferritin (HFn) nanocages for targeted delivery of navitoclax (Nav) to cancer-associated fibroblasts (CAFs) in the tumor microenvironment. The study demonstrates that by functionalizing HFn nanocages with fibroblast activation protein (FAP) antibody fragments, they achieved significantly higher binding with FAP-positive CAFs compared to FAP-negative cancer cells. The navitoclax-loaded nanocages (HNav-FAP) showed enhanced cytotoxicity specifically in FAP-positive cells while maintaining the drug's pro-apoptotic mechanism of action. Importantly, in vivo experiments confirmed that HFn-FAP successfully reached tumors and targeted CAFs after intravenous administration in a mouse model of triple-negative breast cancer.
   Creative Biolabs provided FAP antibody fragments (CAT#: TAB-024WM-F(E)) that were used to functionalize the HFn nanocages. These antibody fragments enabled the selective targeting of CAFs over cancer cells by recognizing FAP, a cell surface glycoprotein highly expressed in the stroma surrounding epithelial cancers but not in healthy tissues. This targeting capability was fundamental to the study's success in developing a promising therapeutic approach that could enhance specific drug delivery into CAFs while overcoming navitoclax's limitations of hydrophobicity and toxicity, potentially opening new avenues for tumor microenvironment-focused cancer therapy.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Protocol & Troubleshooting

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