Human Anti-HLA-A Recombinant Antibody (clone HYB3) (CAT#: PABC-072)
Recombinant Human Antibody (HYB3) is capable of binding to HLA-A1. MAGE-A1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HLA-A1. MAGE-A1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HLA-A1 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. It recognizes the C-terminal half of the MAGE-A1 peptide, the HLA-A1 alpha1-helix, and N-terminal residues of the alpha2-helix, accompanied by a large tilting angle between the two types of molecules within the complex.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
Specifications
- Immunogen
- Human major histocompatibility complex, class I, A
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human HLA-A
- Species Reactivity
- Human
- Clone
- HYB3
- Applications
- WB, ELISA, IF, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Enzyme-Linked Immunosorbent Assay, Immunofluorescence and Flow Cytometry.
Target
- Alternative Names
- HLA-A; major histocompatibility complex, class I, A; HLAA; HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain
- Gene ID
- 3105
- UniProt ID
- P30443
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-500 | Recombinant Anti-human HLA-A Antibody | WB, FC, FuncS | IgG |
| MHH-500 | Recombinant Human Anti-human HLA-A Antibody | ELISA, IP, FuncS | IgG |
| MOB-2307MZ | Recombinant Mouse Anti-Human HLA-A Antibody (clone 9.M.208), Biotin-Conjugated | FC, ICC/IF | Mouse antibody |
| HPAB-1096WJ | Mouse Anti-HLA-A Recombinant Antibody (HPAB-1096WJ) | ELISA | Mouse IgG1 |
| VS3-FY676 | Recombinant Rabbit Anti-HLA-A Antibody (clone R05-5H7) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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