Anti-HLA-A2.1 Antibody-Cytokine Fusion Protein, IL2-IgG (BB7.2) (CAT#: ACFP-SH015)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HLA-A2.1 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HLA-A2.1 as well as the biological activity of IL2. In vitro analysis revealed that the IL2-FuP supported mainly proliferation and lymphokine-activated killer cell activity. IL2 fused immunocytokine significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytokine was designed for treating tumor.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
Specifications
- Target
- HLA-A2.1
- Molecule Class
- IL2-IgG2b
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- BB7.2
- Related Disease
- tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- HLA-A; major histocompatibility complex; class I; A; HLA class I histocompatibility antigen; A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; HLAA; FLJ26655
- Gene ID
- 3105
- UniProt ID
- P30443
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