Anti-HLA-A2.1 Antibody-Cytokine Fusion Protein, IL2-IgG (BB7.2)

CAT#: ACFP-SH015

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HLA-A2.1 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HLA-A2.1 as well as the biological activity of IL2. In vitro analysis revealed that the IL2-FuP supported mainly proliferation and lymphokine-activated killer cell activity. IL2 fused immunocytokine significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytokine was designed for treating tumor.

Gene Expression
Figure 1 IF staining of human cell line A-431 Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)

Specifications

  • Target
  • HLA-A2.1
  • Molecule Class
  • IL2-IgG2b
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • BB7.2
  • Related Disease
  • tumor
  • Cytokine 1
  • IL2
  • Cytokines 1 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • HLA-A; major histocompatibility complex; class I; A; HLA class I histocompatibility antigen; A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; HLAA; FLJ26655
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