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    Anti-HLA-A2.1 Antibody-Cytokine Fusion Protein, IL2-IgG (BB7.2)

    CAT#: ACFP-SH015

    This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HLA-A2.1 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HLA-A2.1 as well as the biological activity of IL2. In vitro analysis revealed that the IL2-FuP supported mainly proliferation and lymphokine-activated killer cell activity. IL2 fused immunocytokine significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytokine was designed for treating tumor.

    Gene Expression
    ❮
    Figure 1 IF staining of human cell line A-431 Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
    ❯

    Specifications

    • Target
    • HLA-A2.1
    • Molecule Class
    • IL2-IgG2b
    • Species Reactivity
    • Human
    • Expression Host
    • CHO
    • Clone
    • BB7.2
    • Related Disease
    • tumor
    • Cytokine 1
    • IL2
    • Cytokines 1 Description
    • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
    • Cytokine 1 Species
    • Human
    • Applications
    • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

    Target

    • Alternative Names
    • HLA-A; major histocompatibility complex; class I; A; HLA class I histocompatibility antigen; A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; HLAA; FLJ26655
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    Datasheet

    Datasheet - ACFP-SH015.pdf

    MSDS

    MSDS - ACFP-SH015.pdf

    COA

    Certificate of Analysis Lookup

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