Anti-HLA-A2.1 Antibody-Cytokine Fusion Protein, TNF-IgG (BB7.2)
CAT#: ACFP-SH016
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HLA-A2.1 IgG to TNF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HLA-A2.1 as well as the biological activity of TNF. In vitro analysis revealed that the TNF-FuP stimulated cytokine production and cytotoxic activity of monocytes and, to a low degree, of T cells. TNF-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytokine was designed for treating tumor.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
❮
❯
Specifications
- Target
- HLA-A2.1
- Molecule Class
- TNF-IgG2b
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- BB7.2
- Related Disease
- tumor
- Cytokine 1
- TNF
- Cytokines 1 Description
- Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, Psoriasis and inflammatory bowel disease (IBD). While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ACFP-SH016. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone BB7.2"
See other products for "HLA-A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-500 | Recombinant Anti-human HLA-A Antibody | WB, FC, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-500-F(E) | Recombinant Anti-human HLA-A Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-500-S(P) | Recombinant Anti-human HLA-A Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-500 | Recombinant Human Anti-human HLA-A Antibody | ELISA, IP, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-500-F(E) | Recombinant Human Anti-human HLA-A Antibody Fab Fragment | WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-500-S(P) | Recombinant Human Anti-human HLA-A Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L022F | anti-HLA-A immunotoxin Fib75 (IgG)-α-sar | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-072 | Human Anti-HLA-A Recombinant Antibody (clone HYB3) | WB, ELISA, IF, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-072 | Human Anti-HLA-A Recombinant Antibody (clone HYB3); Fab Fragment | WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-072 | Human Anti-HLA-A Recombinant Antibody (clone HYB3); scFv Fragment | WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2307MZ | Recombinant Mouse Anti-Human HLA-A Antibody (clone 9.M.208), Biotin-Conjugated | FC, ICC, IF | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-105 | Recombinant Human Anti-HLA-A Antibody (T1) | WB, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-105-S (P) | Recombinant Human Anti-HLA-A Antibody scFv Fragment (T1) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC594 | E*01:03/Human HLA-A leader 3-11 (VMAPRTLVL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC595 | E*01:01/Human HLA-A leader 3-11 (VMAPRTLVL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC646 | PE-E*01:03/Human HLA-A*02, A*24 leader R5K (VMAPKTLVL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC647 | PE-E*01:01/Human HLA-A*02, A*24 leader R5K (VMAPKTLVL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC664 | E*01:03/Human HLA-A*02, A*24 leader (VMAPRTLVL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1067 | PE-DRB1*02:01/Human HLA-A (VGSDWRFLRGYHQYA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1865 | PE-DRB1*01:01/Human HLA-A (GSDARFLRGYHLYA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1068 | APC-DRB1*02:01/Human HLA-A (VGSDWRFLRGYHQYA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1866 | APC-DRB1*01:01/Human HLA-A (GSDARFLRGYHLYA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1069 | BV421-DRB1*02:01/Human HLA-A (VGSDWRFLRGYHQYA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1617 | Rabbit Anti-HLA-A Recombinant Antibody (clone DS1617AB) | FC, ICC, IF, IHC-Fr, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0349CQ | Mouse Anti-HLA-A Recombinant Antibody (clone 2D7sc(Fv)2) | WB, FC | Mouse sc(Fv)2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1096WJ-S(P) | Mouse Anti-HLA-A Recombinant Antibody; scFv Fragment (HPAB-1096WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1096WJ-F(E) | Mouse Anti-HLA-A Recombinant Antibody; Fab Fragment (HPAB-1096WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY124 | AbPlus™ Anti-HLA-A Magnetic Beads (HC10) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY119 | CytoStream™ Mouse Anti-HLA-A Recombinant Antibody (clone 1082C5) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1028 | Anti-HLA-A Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC433 | Recombinant Anti-HLA-A Vesicular Antibody, EV Displayed (VS-0425-YC433) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3164 | Anti-Human HLA-A Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC89 | Anti-HLA-A Antibody Prodrug, Protease Activated (HYB3) | ISZ, Cyt, FuncS |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
