Anti-Il-17A antibody is a Human antibody of IgG class that binds to an Il-17A. This antibody can potently neutralize the effects of recombinant and native human IL-17A.
Figure 1 IL-17A-induced responses and their inhibition by CAT-2200.
(a) Inhibition of FLAG-tagged IL-17A binding to IL-17RA-Fc using HTRF. Triangles, untagged E.-coli-derived IL-17A; circles, CAT-2200; squares, isotype control antibody. (b) Recombinant E.-coli-derived IL-17A induced IL-8 release from primary human chondrocytes. Mean ± SD for one donor (n= 3). EC50= 0.46 nM. (c) CAT-2200-mediated inhibition of E. coli IL-17A (2 nM) induced IL-8 release from primary human chondrocytes. Mean ± SEM for three donors. Mean IC50= 1.56 nM. (d) CAT-2200-mediated inhibition of T-cellderived IL-17A induced IL-6 release from HT1080 cells compared to isotype control. Mean ± SEM for experiments using different T-cell supernatants.
Gerhardt, S., Abbott, W. M., Hargreaves, D., Pauptit, R. A., Davies, R. A., Needham, M. R., ... & Dawson, S. (2009). Structure of IL-17A in complex with a potent, fully human neutralizing antibody. Journal of molecular biology, 394(5), 905-921.
Figure 2 Wall-eyed stereo representation of the IL-17A epitope recognized by CAT-2200.
Residues from the IL-17A homodimer are shown in pale or dark yellow. Residues from the Fab fragments are shown with the light chain in blue and with the heavy chain in green. Labelled residues allow the interactions listed in Table 2 to be readily located. Residues inbrackets are the equivalent residue in IL-17F. When no residue in brackets is indicated, then it is identical between IL-17A and IL-17F.
Gerhardt, S., Abbott, W. M., Hargreaves, D., Pauptit, R. A., Davies, R. A., Needham, M. R., ... & Dawson, S. (2009). Structure of IL-17A in complex with a potent, fully human neutralizing antibody. Journal of molecular biology, 394(5), 905-921.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-069 | Anti-Human IL17A Recombinant Antibody (Secukinumab) | IF, IHC, ELISA, FC | IgG1 - kappa |
TAB-078ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-078ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
TAB-079ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-079ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
TAB-080ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-080ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
PABX-116-F (E) | Recombinant Human Anti-Il-17A Antibody Fab Fragment (CAT-2200) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H57 | Anti-Human IL17A Recombinant Antibody (Perakizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
TAB-H08 | Anti-Human IL17A Recombinant Antibody (Bimekizumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
TAB-048ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) | ELISA, Neut | Human scFv |
TAB-458CQ | Anti-Human IL17A Recombinant Antibody (Vunakizumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-399CL | Human Anti-IL17A Recombinant Antibody (TAB-399CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-030ZJ | Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ) | ELISA, Neut | Mouse IgG |
TAB-030ZJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-030ZJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E)) | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-077LC | Recombinant Anti-Human IL17A Antibody (Fc glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0289MZ | Chicken Anti-Interleukin-17a Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1202CQ | Mouse Anti-IL17A Recombinant Antibody (clone 665909) | Neut | Mouse IgG2a |
NEUT-1203CQ | Mouse Anti-IL17A Recombinant Antibody (clone M273) | Neut | Mouse IgG1 |
NEUT-1204CQ | Mouse Anti-IL17A Recombinant Antibody (clone 403D10.01) | Neut, FC | Mouse IgG1 |
NEUT-1205CQ | Mouse Anti-IL17A Recombinant Antibody (clone 408H6.01) | Neut, ELISA, FC | Mouse IgG2a |
NEUT-1224CQ | Rat Anti-Il17a Recombinant Antibody (clone TC11-18H10.1) | ELISA, CyTOF, ELISPOT, Neut, WB, ICFC | Rat IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0207-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0207-LSX-F(E)) | ELISA | Human Fab |
HPAB-0208-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0208-LSX-F(E)) | ELISA | Human Fab |
HPAB-0209-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0209-LSX-F(E)) | ELISA | Chimeric Fab |
HPAB-0210-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0210-LSX-F(E)) | ELISA | Humanized Fab |
HPAB-0211-LSX-F(E) | Rat Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0211-LSX-F(E)) | ELISA | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-042CN | Mouse Anti-IL17A Recombinant Antibody (NS-042CN) | ELISA, FC | Mouse IgG |
NS-042CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E)) | ELISA, FC | Mouse Fab |
NS-042CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P)) | ELISA, FC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0862-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0862-CN) | WB, ELISA, IP | Mouse IgG |
HPAB-0863-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0863-CN) | WB, ELISA | Mouse IgG |
HPAB-0864-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0864-CN) | WB, ELISA, FC, IHC | Mouse IgG |
HPAB-0865-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0865-CN) | ELISA, Neut | Mouse IgG |
HPAB-0866-CN | Human Anti-IL17A Recombinant Antibody (HPAB-0866-CN) | ELISA, Neut | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0301LY-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0301LY-S(P)) | Neut, ELISA | Human scfv |
HPAB-0704-WJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone HC2C1); scFv Fragment | ELISA | Human scFv |
HPAB-0705-WJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone LC2C1); scFv Fragment | ELISA | Human scFv |
HPAB-0706-WJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone 2C1LCHC); scFv Fragment | ELISA | Human scFv |
HPAB-1747-FY-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-1747-FY-F(E)) | WB, ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-458CQ | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Vunakizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
AFC-TAB-069 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Secukinumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-H08 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Bimekizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-H57 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Perakizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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