How does this antibody affect HGF binding?

This recombinant human antibody has been shown to inhibit HGF binding to c-Met expressed on H1993 cells in ELISA assays. It acts by binding to the MET receptor, thereby blocking the interaction with its ligand, hepatocyte growth factor.

What diseases is this antibody potentially useful for researching?

This antibody can be used in disease research including Carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain. The MET proto-oncogene is often associated with these malignancies, making this antibody a valuable tool for studying them.

Human Anti-MET Recombinant Antibody (TAB-023MZ)

CAT#: TAB-023MZ

This product is a recombinant human antibody to Met/c-Met, a receptor-like tyrosine kinase. The antibody was used to inhibit HGF binding to c-Met expressed on H1993 cells by ELISA. The antibody is recommended for ELISA, Flow cytometry. The antibody can be used in the desease research including Carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

❮

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Specifications

Host Species
Human

Type
Human IgG

Specificity
Human Met/c-Met

Species Reactivity
Human

Applications
Enzyme-linked Immunosorbent Assay, Flow Cytometry

Related Disease
Carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
See the COA

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase

Gene ID
4233

UniProt ID
A0A024R759

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Breast cancer biomarkers at key points during disease progression

Inhibits HGF Binding

We used this antibody to inhibit HGF binding to c-Met in our cell-based ELISA assays using H1993 cells. It worked as described, effectively blocking the interaction. A great tool for studying this receptor tyrosine kinase.

Verified For Flow Cytometry

This recombinant human antibody was verified for use in flow cytometry in our lab. It specifically recognizes the MET receptor. The purity and quality of the antibody are high, consistent with our previous purchases.

Q&As

How does this antibody affect HGF binding?

A: This recombinant human antibody has been shown to inhibit HGF binding to c-Met expressed on H1993 cells in ELISA assays. It acts by binding to the MET receptor, thereby blocking the interaction with its ligand, hepatocyte growth factor.
What diseases is this antibody potentially useful for researching?

A: This antibody can be used in disease research including Carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain. The MET proto-oncogene is often associated with these malignancies, making this antibody a valuable tool for studying them.

View the frequently asked questions answered by Creative Biolabs Support.

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-023MZ.pdf

MSDS

MSDS - TAB-023MZ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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TAB-535LC	Mouse Anti-MET Recombinant Antibody (TAB-535LC)	FC, FuncS, Inhib	Mouse IgG

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TAB-536LC	Human Anti-MET Recombinant Antibody (TAB-536LC)	Inhib	Human IgG2

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TAB-537LC	Human Anti-MET Recombinant Antibody (TAB-537LC)	Inhib	Human IgG2

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TAB-001MZ	Anti-Human MET Recombinant Antibody (DN30)	IHC, PET imaging

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TAB-002MZ	Anti-Human MET Recombinant Antibody (TAB-002MZ)	IHC, PET imaging	Chimeric antibody (mouse/human)

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TAB-011MZ	Mouse Anti-MET Recombinant Antibody (TAB-011MZ)	ELISA, WB, FC	Mouse IgG

CAT	Product Name	Application	Type
TAB-012MZ	Mouse Anti-MET Recombinant Antibody (TAB-012MZ)	ELISA, WB, FC	Mouse IgG

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TAB-002MZ-S(P)	Anti-Human MET Recombinant Antibody scFv Fragment (TAB-002MZ-S(P))	IHC, PET imaging	Chimeric antibody (mouse/human)

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TAB-002MZ-F(E)	Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E))	IHC, PET imaging	Chimeric antibody (mouse/human)

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TAB-0880CLV-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E))	ELISA, FuncS	Chimeric (mouse/human) Fab

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MOB-1226CT	Recombinant Mouse anti-Human MET Monoclonal antibody (9G22)	IHC-Fr, IHC-P

CAT	Product Name	Application	Type
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MOR-2216	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB)	ICC, IF, IHC-P, WB	IgG

CAT	Product Name	Application	Type
MOR-4519	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS)	WB, IF, ICC	IgG

CAT	Product Name	Application	Type
MOR-4645	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS)	WB, IF, ICC, FC, ELISA	IgG

CAT	Product Name	Application	Type
MOR-4694	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS)	WB, ELISA	IgG

CAT	Product Name	Application	Type
HPAB-0071-YC	Mouse Anti-MET Recombinant Antibody (HPAB-0071-YC)	ELISA, Inhib	Mouse IgG

CAT	Product Name	Application	Type
HPAB-0072-YC	Human Anti-MET Recombinant Antibody (HPAB-0072-YC)	ELISA	Humanized IgG1, κ

CAT	Product Name	Application	Type
HPAB-0073-YC	Human Anti-MET Recombinant Antibody (HPAB-0073-YC)	ELISA	Human IgG1, κ

CAT	Product Name	Application	Type
HPAB-0071-YC-S(P)	Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0071-YC-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0072-YC-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0072-YC-S(P))	ELISA	Humanized scFv

CAT	Product Name	Application	Type
HPAB-0073-YC-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0073-YC-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-0071-YC-F(E)	Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0071-YC-F(E))	ELISA	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0072-YC-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0072-YC-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application	Type
HPAB-0073-YC-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0073-YC-F(E))	ELISA	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-H24	Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-1024-XY131	Mouse Anti-NHP MET Recombinant Antibody (clone K.845.5)	WB, IP	Mouse IgG1

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VS-0325-FY58	Human Anti-Met (clone 5D5) scFv-Fc Chimera	Inhib	Human IgG1, scFv-Fc

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VS-0325-XY1336	Anti-MET Immunohistochemistry Kit	IHC

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VS-0525-YC10	Recombinant Anti-MET Biparatopic Antibody, Asymmetric hetero HC-LC	ELISA	Asymmetric hetero HC, common LC

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VS-0525-XY4356	Anti-Human MET Immunohistochemistry Kit	IHC

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