Afuco™ Anti-Human TGFB1 ADCC Recombinant Antibody (LY2382770), ADCC Enhanced

Name: Afuco™ Anti-Human TGFB1 ADCC Recombinant Antibody (LY2382770), ADCC Enhanced
SKU: AFC-583CL
Rating: 5 (1 reviews)

CAT#: AFC-583CL

Anti-TGFB1 ADCC Enhanced Antibody (LY2382770) is an ADCC enhanced antibody produced by our Afuco™ platform. LY 2382770 is a monoclonal antibody inhibitor of transforming growth factor-beta (TGF-β) kinase, for the treatment of kidney disease due to diabetes.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human bone marrow

Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg

Normal Tissue Figure 4 Bone marrow

Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1

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Specifications

Host Species
Humanized

Derivation
Humanized

Type
ADCC enhanced antibody

Species Reactivity
Human

Related Disease
Kidney Disease

Product Property

Purity
>97%, by SDS-PAGE under reducing conditions

Storage
≤1 year at -20°C.

Target

Alternative Names
TGFB1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; transforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1

Gene ID
7040

UniProt ID
P01137

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Related Diseases

Inflammatory Bowel Diseases

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-583CL.pdf

MSDS

MSDS - AFC-583CL.pdf

COA

Certificate of Analysis Lookup

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