Anti-TNFRSF9 immunotoxin (scFv)-Sap (CAT#: AGTO-G063S)
This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF9 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to the cell surface TNFRSF9 and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of graft-versus-host diseas (GVHD) and the relapse of leukemia.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- graft-versus-host diseas (GVHD) and the relapse of leukemia
Target
- Alternative Names
- TNFRSF9; tumor necrosis factor receptor superfamily, member 9; ILA; 4-1BB; CD137; CDw137; tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; saporin; saporin-6; saporin-S60; SAP
- Gene ID
- 3604
- UniProt ID
- Q07011
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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See other products for "TNFRSF9"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1443z | Mouse Anti-TNFRSF9 Recombinant Antibody (clone 29H11) | ELISA, FC, IP, FuncS | Mouse IgG1 |
| MOB-094CQ | Mouse Anti-TNFRSF9 Recombinant Antibody (clone YC148) | ELISA, IP, FC, FuncS | Mouse IgG1, κ |
| MOB-007LC | Rat Anti-Tnfrsf9 Recombinant Antibody (clone YC149) | FuncS | Rat IgG |
| MOB-029LC | Human Anti-TNFRSF9 Recombinant Antibody (clone UtomilumAb) | ELISA, FuncS | Human IgG2 |
| MOB-087LC | Human Anti-TNFRSF9 Recombinant Antibody (MOB-087LC) | ELISA, FC, FuncS | Human IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179 | Anti-Human 4-1BB Recombinant Antibody (Urelumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| TAB-457CQ | Anti-Human TNFRSF9 Recombinant Antibody (Utomilumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-064LC | Recombinant Anti-Human TNFRSF9 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
High-mannose Glycoform
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-064LC-1 | Recombinant Anti-Human TNFRSF9 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0611CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0611CLV) | ELISA, FC | Humanized IgG1 |
| TAB-0612CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0612CLV) | ELISA, FC | Humanized IgG4 |
| TAB-0611CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0611CLV-F(E)) | ELISA, FC | Humanized Fab |
| TAB-0612CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0612CLV-F(E)) | ELISA | Humanized Fab |
| TAB-0611CLV-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0611CLV-S(P)) | ELISA, FC | Humanized scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0613CLV | Human Anti-TNFRSF9 Recombinant Antibody (TAB-0613CLV) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-0613CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0613CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0614CLV-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (TAB-0614CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0613CLV-S(P) | Mouse Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0613CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0614CLV-S(P) | Mouse Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (TAB-0614CLV-S(P)) | ELISA | Mouse scFv |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2167CQ | Rat Anti-Tnfrsf9 Recombinant Antibody (clone CBL332) | Block, WB | Rat IgG2b |
| NEUT-2168CQ | Hamster Anti-Tnfrsf9 Recombinant Antibody (clone 17B5) | FC, Block | Hamster IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2169CQ | Rat Anti-Tnfrsf9 Recombinant Antibody (clone 6J43) | Neut, WB | Rat IgG2 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0253-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0253-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0254-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0254-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0255-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0255-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0256-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0256-CN-F(E)) | FC | Human Fab |
| HPAB-0257-CN-F(E) | Human Anti-TNFRSF9 Recombinant Antibody; Fab Fragment (HPAB-0257-CN-F(E)) | FC | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0053-FY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0053-FY-S(P)) | ELISA | Human scFv |
| HPAB-0843LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0843LY-S(P)) | FC, FuncS | Human scfv |
| HPAB-0844LY-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-0844LY-S(P)) | FC, FuncS | Human scfv |
| HPAB-N0282-YC-S(P) | Human Anti-TNFRSF9 Recombinant Antibody; scFv Fragment (HPAB-N0282-YC-S(P)) | FC | Human scFv |
| HPAB-0670YY-S(P) | Rat Anti-TNFRSF9 Recombinant Antibody (clone LOB12.3); scFv Fragment | ELISA | Rat scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-457CQ | Afuco™ Anti-TNFRSF9 ADCC Recombinant Antibody (Utomilumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-179 | Afuco™ Anti-TNFRSF9 ADCC Recombinant Antibody (Urelumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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