Recombinant Anti-TNFRSF9 Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC236)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human TNFRSF9

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Epitope 1
• A membrane distal epitope centered on amino acid R41 between CRD-3 and CRD-4 of 4-1BB

• Epitope 2
• An epitope on the CRD-1 domian of 4-1BB, away from the ligand binding site.

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, IF, IP

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• TNF Receptor Superfamily Member 9

• Introduction
• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

• Alternative Names
• TNFRSF9; tumor necrosis factor receptor superfamily, member 9; ILA; tumor necrosis factor receptor superfamily member 9; 4 1BB; CD137; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor

• Gene ID
• 3604

• UniProt ID
• Q07011

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