Recombinant Anti-TNFRSF9 Biparatopic Antibody, Tandem scFv

Name: Recombinant Anti-TNFRSF9 Biparatopic Antibody, Tandem scFv
SKU: VS-0525-YC236
Rating: 5 (1 reviews)

CAT#: VS-0525-YC236

The Recombinant Anti-TNFRSF9 Biparatopic Antibody, Tandem scFv A biparatopic antibody (bpAb) was designed for dual epitope recognition on TNFRSF9. This construct features tandem scFv arms for unique, non-overlapping binding. One scFv acts as a ligand-blocking antibody, binding a membrane-distal epitope centered on amino acid R41 between CRDs 3 and 4 of 4-1BB. In contrast, the other scFv binds 4-1BB CRD-1, located away from the ligand binding site.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg

RNA Expression Figure 2 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9

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Specifications

Host Animal 1
Human

Host Animal 2
Human

Specificity
Human TNFRSF9

Species Reactivity
Human

Type
Tandem scFv

Valency
1 + 1

Epitope 1
A membrane distal epitope centered on amino acid R41 between CRD-3 and CRD-4 of 4-1BB

Epitope 2
An epitope on the CRD-1 domian of 4-1BB, away from the ligand binding site.

Purity
>90%

Purification
Affinity purified

Applications
ELISA, IF, IP

Concentration
Lot specific

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

Long Name
TNF Receptor Superfamily Member 9

Target

Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Alternative Names
TNFRSF9; tumor necrosis factor receptor superfamily, member 9; ILA; tumor necrosis factor receptor superfamily member 9; 4 1BB; CD137; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor

Gene ID
3604

UniProt ID
Q07011

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Datasheet

Datasheet - VS-0525-YC236.pdf

MSDS

MSDS - VS-0525-YC236.pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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