Human Anti-TNFRSF9 (clone 39E3) scFv-Fc Chimera (CAT#: VS-0325-FY100)
The anti-CD137 scFv-Fc antibody targets CD137 (4-1BB), a co-stimulatory molecule involved in immune cell activation. It has potential therapeutic applications in cancer immunotherapy and autoimmune diseases. The scFv-Fc format provides extended half-life and enhanced binding affinity, improving its therapeutic potential.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- 39E3 is a human monoclonal antibody specific for human 4-1BB.
- Species Reactivity
- Human
- Clone
- 39E3
- Applications
- Flow Cytometry
- Related Disease
- Cancer, autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- TNF Receptor Superfamily Member 9; T-Cell Antigen 4-1BB Homolog; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; ILA; Interleukin-Activated Receptor, Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily, Member 9
- Gene ID
- 3604
- UniProt ID
- Q07011
- Long Name
- TNF Receptor Superfamily Member 9
- Cellular Localization
- Membrane
- Protein Refseq
- NP_001552.2
- Function
- Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179 | Anti-Human 4-1BB Recombinant Antibody (TAB-179) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| TAB-457CQ | Anti-Human TNFRSF9 Recombinant Antibody (TAB-457CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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