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TNFRSF9

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Protein class

Cancer-related genes, CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (granulocytes, monocytes, T-cells, Langerhans cells, dendritic cells)

Immune cell specificity

Group enriched (T-reg, memory CD8 T-cell, neutrophil, NK-cell)

Cell line specificity

Cell line enriched (HDLM-2)

Interaction

Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.

Molecular function

Receptor

More Types Infomation

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