Recombinant Anti-Human MUC1 Antibody (Non-glycosylated)
CAT#: Gly-121LC
This product is a non-glycosylated mouse monoclonal antibody. HMFGl N56S has increased affinity to human MUC1 and can be potentially used in the treatment of ovarian cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/1789_B9_13_cr596f381e20667_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1986/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/100_E7_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/101_E7_1_blue_red_green.jpg
Normal Tissue
Figure 5 Stomach
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_2_1.jpg
Normal Tissue
Figure 6 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_9_3.jpg
Normal Tissue
Figure 7 Kidney
Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185499-MUC1
❮
❯
Glyco-engineering
- Activity
- Increased affinity to MUC1
Specifications
- Target
- MUC1 (Mucin 1)
- Host Species
- Mouse
- Type
- Mouse antibody
- Specificity
- Human
- Clone
- HMFGl N56S
- Applications
- ELISA
Target
- Alternative Names
- MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-
- Related Disease
- Ovarian cancer
- Gene ID
- 4582
- UniProt ID
- P15941
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Reliable for Cancer Biomarker Studies
The Recombinant Anti-Human MUC1 Antibody has significantly improved our cancer biomarker research. Its non-glycosylated form ensures accuracy in detecting MUC1, a crucial biomarker in various cancers. Creative Biolabs' commitment to quality is evident, with excellent support and prompt delivery ensuring our studies proceed smoothly.
Unparalleled Specificity and Performance
Our team uses this antibody in ELISA to study MUC1 expression, crucial in our breast cancer research. The antibody's specificity and non-glycosylated nature minimize variability, delivering consistent results crucial for longitudinal studies. The purchasing and support experience with Creative Biolabs has been outstanding.
Consistent Results in MUC1 Quantification
Producing consistent results, this antibody has been core to our assays quantifying MUC1 levels in cancer cell lines. Its non-glycosylated variant provides an edge in accuracy, proving essential for detailed analyses and supporting our research hypotheses robustly.
Q&As
-
What is the significance of the Anti-Human MUC1 Antibody in research?
A: This Recombinant Anti-Human MUC1 Antibody is valuable in studying MUC1, a mucin protein that is often overexpressed in epithelial cancers such as breast and ovarian cancers. It helps in understanding the role of MUC1 in tumor progression, metastasis, and therapy resistance, providing insights that are crucial for developing targeted cancer therapies.
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How does the non-glycosylated form of the antibody enhance research applications?
A: The non-glycosylated variant of the Anti-MUC1 Antibody allows for more accurate studies of protein interactions that may be affected by glycosylation processes. This form provides more consistent results, eliminating potential variations introduced by glycan structures, which is critical for understanding the core functions and interactions of MUC1.
-
How does this antibody aid in ovarian cancer research?
A: The increased affinity of the non-glycosylated form enhances its utility in ovarian cancer research by providing precise detection of MUC1. Its role as a biomarker facilitates the tracking of disease progression and the evaluation of therapeutic response, aiding in better clinical outcomes.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-166 | Humanized Anti-MUC1 Recombinant Antibody (clone Cantuzumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Humanized (from mouse) IgG1, κ |
| TAB-037-F(E) | Anti-Human MUC1 Recombinant Antibody Fab Fragment (TAB-037-F(E)) | Neut, ELISA, IF, IP, FuncS, FC, IHC | Fab - G1 - kappa |
| TAB-413MZ-S(P) | Human Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-413MZ-S(P)) | ELISA | Humanized scFv |
| TAB-425MZ-S(P) | Anti-Human MUC1 Recombinant Antibody scFv Fragment (huDMB5F3) | FC | Humanized antibody |
| TAB-430MZ-S(P) | Anti-Human MUC1 Recombinant Antibody scFv Fragment (BLC595) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L036E | anti-MUC1 immunotoxin C242 (Fab)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L064E | anti-MUC1 immunotoxin H23 (scFv)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0388CL-S(P) | Mouse Anti-Human MUC1 Recombinant Antibody scFv Fragment | WB, IHC | |
| TAB-411MZ | Mouse Anti-MUC1 Recombinant Antibody (TAB-411MZ) | ELISA | Mouse IgG |
| TAB-416MZ | Mouse Anti-MUC1 Recombinant Antibody (TAB-416MZ) | Block | Mouse IgG |
| TAB-417MZ | Mouse Anti-MUC1 Recombinant Antibody (TAB-417MZ) | IF | Mouse IgG |
| TAB-418MZ | Mouse Anti-MUC1 Recombinant Antibody (TAB-418MZ) | ELISA, FuncS, IHC, IF, FC, ADCC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0278CL-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-0278CL-F(E)) | ELISA, Internalization, BI, FuncS | Human Fab |
| TAB-431MZ-S(P) | Anti-Human MUC1 Recombinant Antibody scFv Fragment (PH1) | ELISA, WB, FC, IHC | Human antibody |
| TAB-432MZ-S(P) | Human Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-432MZ-S(P)) | ELISA, FC | Human scFv |
| PABX-143 | Recombinant Human Anti-MUC1 Antibody (CTM01) | WB, ELISA, FuncS | IgG |
| PABX-143-F (E) | Recombinant Human Anti-MUC1 Antibody Fab Fragment (CTM01) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-412MZ | Human Anti-MUC1 Recombinant Antibody (TAB-412MZ) | ELISA | Chimeric (mouse/human) IgG |
| TAB-412MZ-S(P) | Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-412MZ-S(P)) | ELISA | Mouse scFv |
| TAB-412MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-412MZ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-012LC | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) | ELISA, FC, IHC | Humanized antibody |
| Gly-120LC | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-012LC-1 | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) | ELISA, FC, IHC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-109LC | Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-122LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| Gly-124LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0379MZ | Chicken Anti-MUC1 Polyclonal IgY | IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC096 | PE-A*02:01/Human MUC1 (LLLLTVLTV) MHC Tetramer | FCM | |
| MHC-LC097 | APC-A*02:01/Human MUC1 (LLLLTVLTV) MHC Tetramer | FCM | |
| MHC-LC781 | A*0201/Human MUC-1 (LLLLTVLTV) MHC Tetramer | FCM | |
| MHC-LC1950 | PE-A2/Human MUC1 (NLTISDVSV) MHC Tetramer | FCM | |
| MHC-YF272 | A*02:01/Human MUC1 (LLLLTVLTV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2320 | Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) | IHC-P, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0838LC | Recombinant Mouse Anti-Human MUC1 Antibody (SM3) | ELISA | IgG1 |
| EPAF-0581CQ | Recombinant Mouse Anti-Human MUC1 Antibody (B27.29) | Neut, FC | IgG1 |
| EPAF-0583CQ | Recombinant Mouse Anti-Human MUC1 Antibody (BC4E549) | Neut, FC | IgG1 |
| EPAF-0584CQ | Recombinant Mouse Anti-Human MUC1 Antibody (DF3) | Neut, FC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0091-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0091-YC-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0094-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody (clone 12D10); Fab Fragment | ELISA, FC | Mouse Fab |
| PFBC-399 | Mouse Anti-MUC1 Recombinant Antibody (clone AR20.5); Fab Fragment | ELISA, FC, FuncS | Mouse Fab |
| HPAB-0495-FY-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0495-FY-F(E)) | ELISA | Human Fab |
| HPAB-0496-FY-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0496-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-399 | Mouse Anti-MUC1 Recombinant Antibody (clone AR20.5); scFv Fragment | ELISA, FC, FuncS | Mouse scFv |
| PSBC-400 | Mouse Anti-MUC1 Recombinant Antibody (clone SM3); scFv Fragment | FC, IHC-Fr, IF, ELISA, IHC-P | Mouse scFv |
| HPAB-J0212-YC-S(P) | Mouse Anti-MUC1 Recombinant Antibody (clone BW835); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1159WJ-S(P) | Mouse Anti-MUC1 Recombinant Antibody (clone 12E); scFv Fragment | ELISA, ICC | Mouse scFv |
| HPAB-1160WJ-S(P) | Mouse Anti-MUC1 Recombinant Antibody (clone 3D); scFv Fragment | ELISA, ICC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H56 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H56) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-H65 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H65) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-026ML | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-026ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-166 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-166) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-H77 | Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) | ELISA, FC, IP, FuncS, IF | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP745-YC | Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP745-YC) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-1070F | Mouse Anti-MUC1 Recombinant Antibody (clone OVTL16) | IA | Mouse IgG1 |
| VS3-WK788 | Rabbit Anti-MUC1 Recombinant Antibody (clone SN06-80) | WB, ICC, IHC, FC | Rabbit IgG |
| VS3-CJ682 | Mouse Anti-MUC1 Recombinant Antibody (VS3-CJ682) | WB, IHC | Mouse IgG2b |
| VS3-XY1122 | Mouse Anti-MUC1 Recombinant Antibody (clone CA009) | IHC, WB | Mouse IgG |
| VS-0724-XY87 | Human Anti-MUC1 Recombinant Antibody (clone MB5) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY192 | AbPlus™ Anti-MUC1 Magnetic Beads (139H2) | IP, Protein Purification | |
| VS-0724-YC1494 | AbPlus™ Anti-MUC1 Magnetic Beads (VS-0724-YC1494) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY26 | Human Anti-MUC1 (clone 1B2) scFv-Fc Chimera | FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY169 | CytoStream™ Mouse Anti-MUC1 Recombinant Antibody (VS-0225-XY169) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1394 | Anti-MUC1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4575 | Anti-Human MUC1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4576 | Anti-Mouse MUC1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC379 | Recombinant Anti-MUC1 Vesicular Antibody, EV Displayed (VS-0425-YC379) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC131 | Recombinant Anti-MUC1 Biparatopic Antibody, Tandem scFv | ELISA, IHC | Tandem scFv |
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