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Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) (CAT#: Gly-012LC)

This product is a humanized monoclonal antibody with N-glycosylation sites at CDR2 of VH. The glycosylation in CDR2 increased the half-life of the antibody. hPM specifically binds human MUC1 and can be potentially used in the treatment of ovarian cancer.

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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RPTEC TERT1
Figure 1 IF staining of human cell line RPTEC TERT1
(Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/1789_B9_13_cr596f381e20667_selected.jpg
Figure 2 IHC staining of human stomach
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1986/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/100_E7_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/101_E7_1_blue_red_green.jpg
Normal Tissue
Figure 5 Stomach
Figure 5 Stomach
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_2_1.jpg
Figure 6 Colon
Figure 6 Colon
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_9_3.jpg
Figure 7 Kidney
Figure 7 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_8_5.jpg
Figure 8 Testis
Figure 8 Testis
(Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185499-MUC1

Glyco-engineering

  • Glycosylation site
  • CDR2 of VH
  • Glycosylation Type
  • N-glycosylation
  • Activity
  • Increased half-life

Specifications

  • Target
  • MUC1 (Mucin 1)
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Antibody Isotype
  • IgG
  • Clone
  • hPM (humanized Pankomab)
  • Expression Host
  • GT-5s (Fuc+)
  • Applications
  • ELISA, FC, IHC

Target

  • Alternative Names
  • MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-
  • Related Disease
  • Ovarian cancer

Downloads

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See other products for "Clone hPM (humanized Pankomab)"

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Please select product type
Single-domain Antibody Humanized Antibody Mouse Antibody Immunotoxin Human Antibody Chimeric Antibody Sialylated IgG Glycan Fc Glycosylation Fab Glycosylation Deglycosylated Antibody (Non-glycosylated IgGs) Chicken IgY Antibody MHC Tetramer for Cancer Rabbit Monoclonal Antibody Epitope-Specific Antibody Recombinant Antibody scFv Fragment Antibody Fab Fragment Antibody ADCC Enhanced Antibody
CAT Product Name Application Type
NAB-2049-VHH Recombinant Anti-human MUC1 VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH
HPAB-AP504-YC Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) FC Camel VHH
HPAB-AP505-YC Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) ELISA Camel VHH
HPAB-0736-YJ-VHH Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) ELISA Camelid VHH
HPAB-0737-YJ-VHH Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) ELISA Camelid VHH

Customer Reviews and Q&As

Customer Review Q&As

Submit a review or a question

  • Dependable stability and storage
    Storage and stability have been very reliable. We accidentally left the antibody at 4°C for a week, but it retained its activity, proving to be very robust.
  • Reduced immunogenic responses after modification
    The glycosylation/sialylation modification truly makes a difference. We've seen improved performance in our in vivo studies with reduced immunogenic responses.
  • High Credibility in ELISA
    The specificity of this antibody has greatly improved the reliability of our ELISA experiments. The glycosylation process ensures a stable and constant performance.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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