Anti-Human MUC1 Recombinant Antibody (TAB-173) (CAT#: TAB-173)

Recombinant monoclonal antibody to MUC1. It is a humanized monoclonal antibody designed for the treatment of cancers. The antibody is linked to a cytotoxic agent, ravtansine.

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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • Synthetic peptide, corresponding to residues from the C-terminus of Human MUC1.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • Related Disease
  • Gastric cancers (metastatic or locally advanced)

Product Property

  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Target

  • Alternative Names
  • Cantuzumab ravtansine;868747-45-9;C242-DM4;huC242-SPDB-DM4;MUC1;mucin 1, cell surface associated;mucin 1, transmembrane , PUM;mucin-1;CD227;PEM;episialin;DF3 antigen;H23 antigen;krebs von den Lungen-6;mucin 1, transmembrane;tumor-associated mucin;carcinom

Related Resources

  • Citations

Wu, Zhengliang L., et al. "Detecting substrate glycans of fucosyltransferases with fluorophore-conjugated fucose and methods for glycan electrophoresis." Glycobiology 30.12 (2020): 970-980. https://doi.org/10.1093/glycob/cwaa030

This study introduces a novel method for detecting substrate glycans of fucosyltransferases using fluorophore-conjugated fucose and gel electrophoresis techniques. The researchers demonstrated that various fucosyltransferases (FUT2, FUT6, FUT7, FUT8, and FUT9) can recognize and transfer fluorophore-conjugated fucose to their substrate glycans on glycoproteins. This approach allowed for the visualization and characterization of substrate glycans on fetal bovine fetuin, recombinant H1N1 viral neuraminidase, and therapeutic antibodies. The study established electrophoresis-based methods for analyzing free glycans, enabling the researchers to track the enzymatic synthesis of Lewis X and sialyl Lewis X structures. Importantly, the research revealed that fucosylation occurs at a much faster rate than sialylation, suggesting that fucosyltransferases are key regulatory targets in the synthesis of these important glycan epitopes.
Creative Biolabs provided Cantuzumab, an anti-Muc1 therapeutic antibody that lacks core-6 fucosylation. This antibody served as a critical test substrate for demonstrating FUT8's ability to incorporate fluorophore-conjugated fucose into substrate glycans, particularly for comparing glycan structures between antibodies with and without core fucosylation. The availability of this specialized therapeutic antibody enabled the researchers to clearly identify and characterize the substrate specificities of different fucosyltransferases, which has important implications for understanding glycan epitope regulation and potentially for developing targeted therapeutic interventions.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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