Mouse Anti-MUC1 Recombinant Antibody (clone 12D10) (CAT#: HPAB-0094-YC)

The provided is an antibody, an antigen-binding fragment thereof or a MUC1-binding molecule, having, for example, 40-fold specificity or more for a cancer-associated structure of MUC1 as compared to that of a normal tissue-associated structure of MUC1.

Specific Inquiry Online Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FC

Figure 1 shows an experimental result of examination with FACS of whether a MUC1 protein expressed on a cancer cell membrane surface binds to a 12D10 antibody or not.

Figure 1 shows an experimental result of examination with FACS of whether a MUC1 protein expressed on a cancer cell membrane surface binds to a 12D10 antibody or not.

The graphs show the result of analysis by FACS Aria. The left part indicates the result on a breast cancer cell T-47D, the center part indicates a human lung cancer cultured cell, Calu-3 cell, and the right part indicates the result on a mammary gland epithelial cell 184A which as a control. A dotted line indicates a control IgG, and a solid line indicates the 12D10 antibody. From this result, it was demonstrated that the 12D10 antibody strongly reacts with a breast cancer celland a lung cancer cell, but hardly reacts with a mammary gland epithelial cell

Figure 2 shows a standard curve for quantification of MUC1 by a sandwich immunoassay using the antibody 12D10.

Figure 2 shows a standard curve for quantification of MUC1 by a sandwich immunoassay using the antibody 12D10.


Specifications

  • Immunogen
  • STn (DT*R)-20-Cys
  • Host Species
  • Mouse
  • Type
  • Mouse IgG2a
  • Specificity
  • Human MUC1
  • Species Reactivity
  • Human
  • Clone
  • 12D10
  • Applications
  • ELISA, FC
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 12D10"

See other products for "MUC1"

Immunotoxin

CAT Product Name Application Type
AGTO-L036E anti-MUC1 immunotoxin C242 (Fab)-PE Cytotoxicity assay, Functional assay
AGTO-L064E anti-MUC1 immunotoxin H23 (scFv)-PE Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-0278CL Human Anti-MUC1 Recombinant Antibody (TAB-0278CL) ELISA, Internalization, BI, FuncS Human IgG
TAB-0278CL-S(P) Human Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-0278CL-S(P)) ELISA, Internalization, BI, FuncS Human scFv
TAB-0278CL-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-0278CL-F(E)) ELISA, Internalization, BI, FuncS Human Fab
TAB-431MZ-F(E) Anti-Human MUC1 Recombinant Antibody Fab Fragment (PH1) ELISA, WB, FC, IHC Human antibody
PABX-143 Recombinant Human Anti-MUC1 Antibody (CTM01) WB, ELISA, FuncS IgG

Fab Glycosylation

CAT Product Name Application Type
Gly-012LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody
Gly-120LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) ELISA Mouse antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-012LC-1 Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-109LC Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) ELISA Human antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0379MZ Chicken Anti-MUC1 Polyclonal IgY IHC, WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2320 Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) IHC-P, IHC-Fr IgG

Recombinant Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H56 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Pemtumomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-H65 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Sontuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-026ML Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-166 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Cantuzumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-H77 Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) ELISA, FC, IP, FuncS, IF IgG1, κ

Submit a review or a question
There are currently no Customer reviews or questions for HPAB-0094-YC. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Go to compare

    Go to compare