Products
Loading...

MUC1

More+
MUC1 is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, IHC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, IHC
Derivation:
Humanized
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
CanAg
Linker:
PEG4Mal
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CanAg
Linker:
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CanAg
Linker:
sulfo-SPDB (sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CanAg
Linker:
SPDB
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CanAg
Linker:
SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CAIX, Carbonic anhydrase IX
Linker:
mcc (Maleimidomethyl cyclohexane-1-carboxylate)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CA6, a specific glycol-epitope of MUC-1
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CanAg
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CanAg
Linker:
SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
Drug:
DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Target:
CanAg
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
Mucin1
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
MUC1
Linker:
CL2A
Drug:
SN-38(7-ethyl-10-hydroxy camptothecin)
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Increase Efficiency to Accelerate Your Research & Discovery Process

Increase Efficiency to Accelerate Your Research & 
Discovery Process

Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production ...

Find out more >

USA

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356

Europe

Tel: 44-207-097-1828
Email:
Follow us on:
        

Terms of Service-Privacy Policy     © 2007 - 2019 Creative-Biolabs All Rights Reserved