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MUC1

rAbs(232)
Glyco-Abs(8)
MHC(7)
More+
MUC1 is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.

Anti-Human MUC1 Therapeutic Antibody (Cantuzumab Ravtansine) (TAB-173)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Inquiry
Anti-MUC1 Therapeutic Antibody (Epitumomab Cituxetan) (TAB-745)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, IHC
Inquiry
Anti-Human MUC1 Therapeutic Antibody (Pemtumomab) (TAB-H56)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Inquiry
Anti-Human MUC1 Therapeutic Antibody (Sontuzumab) (TAB-H65)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Inquiry
Anti-Human MUC1 Therapeutic Antibody (Cantuzumab Mertansine) (TAB-166)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Inquiry
Anti-MUC1 Therapeutic Antibody (Nacolomab Tafenatox) (TAB-765)
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, ICC
Inquiry
Anti-Human MUC1 Therapeutic Antibody Fab Fragment (Clivatuzumab Tetraxetan) (TAB-037-F(E))
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, IHC
Inquiry
Anti-Human MUC1 Therapeutic Antibody (Yttrium (90 Y) Clivatuzumab Tetraxetan) (TAB-H77)
Derivation:
Humanized
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Inquiry
anti-MUC1 immunotoxin C242 (Fab)-PE (AGTO-L036E)
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Inquiry
Anti-CanAg (huC242)-Mal-dPEG4-NHS-DM1 ADC (ADC-008LCT)
Target:
CanAg
Linker:
PEG4Mal
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Inquiry
Anti-CanAg (huC242)-SMCC-DM1 ADC (ADC-009LCT)
Target:
CanAg
Linker:
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Inquiry
Anti-CanAg (huC242)-Sulfo-SPDB-DM4 ADC (ADC-010LCT)
Target:
CanAg
Linker:
sulfo-SPDB (sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Inquiry
Anti-CanAg (huC242)-SPDB-DM4 ADC (ADC-011LCT)
Target:
CanAg
Linker:
SPDB
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Inquiry
Anti-CanAg (huC242)-SPP-DM1 ADC (ADC-012LCT)
Target:
CanAg
Linker:
SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Inquiry
Anti-CAIX-mcc-MMAE ADC (ADC-013LCT)
Target:
CAIX, Carbonic anhydrase IX
Linker:
mcc (Maleimidomethyl cyclohexane-1-carboxylate)
Drug:
MMAE (Monomethyl auristatin E)
Inquiry
Anti-CA6 (clone huDS6)-SPDB-DM4 ADC (ADC-012LZY)
Target:
CA6, a specific glycol-epitope of MUC-1
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Inquiry
Anti-CanAg (clone huC242)-SPDB-DM4 ADC (ADC-092LZY)
Target:
CanAg
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Inquiry
Anti-CanAg (clone huC242)-SMCC-DM1 ADC (ADC-102LZY)
Target:
CanAg
Linker:
SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
Drug:
DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Inquiry
Anti-CanAg (clone huC242)-SPDB-DM4 ADC (ADC-103LZY)
Target:
CanAg
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Inquiry
Anti-Mucin1-DM4 ADC (ADC-112LZY)
Target:
Mucin1
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Inquiry
Anti-MUC1 (clone hPAM4)-CL2A-SN-38 ADC (ADC-162LZY)
Target:
MUC1
Linker:
CL2A
Drug:
SN-38(7-ethyl-10-hydroxy camptothecin)
Inquiry
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