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MUC1

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This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, IHC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, IHC
Derivation:
Humanized
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Targets:
MUC1 & CD3
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, IP, ChiP, Neut, ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, Neut, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IP, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, Neut, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
mucin
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Target:
CanAg
Linker:
PEG4Mal
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CanAg
Linker:
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CanAg
Linker:
sulfo-SPDB (sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CanAg
Linker:
SPDB
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CanAg
Linker:
SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CAIX, Carbonic anhydrase IX
Linker:
mcc (Maleimidomethyl cyclohexane-1-carboxylate)
Drug:
MMAE (Monomethyl auristatin E)
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