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MUC1
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Recombinant Anti-Human MUC1 Antibody Fab Fragment (MOB-1077z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, IF, FuncS
Recombinant Anti-Human MUC1 Antibody (MOB-1077z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Neut, FuncS
Recombinant Anti-Human MUC1 Antibody scFv Fragment (MOB-1077z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
Mouse Anti-MUC1 Recombinant Antibody (PABL-662)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, FuncS
Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (PFBL-656)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, IF, FuncS
Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (PSBL-656)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, IF, FuncS
Anti-CanAg (clone huC242)-SPP-DM1 ADC (ADC-209LZY)
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- Target: CanAg
- Linker: SPP(N-succinimidyl 4-(2-pyridyldithio)pentanoate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Anti-MUC1 (clone hPAM4)-CL2A-SN-38 ADC (ADC-162LZY)
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- Target: MUC1
- Linker: CL2A
- Drug: SN-38(7-ethyl-10-hydroxy camptothecin)
Anti-CanAg (huC242)-SMCC-DM1 ADC (ADC-009LCT)
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- Target: CanAg
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Anti-CA6 (clone huDS6)-SPDB-DM4 ADC (ADC-012LZY)
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- Target: CA6, a specific glycol-epitope of MUC-1
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Anti-CanAg (clone huC242)-SPDB-DM4 ADC (ADC-092LZY)
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- Target: CanAg
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Anti-mucin (clone hPAM4)-SN-38 ADC (ADC-121CL)
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- Target: mucin
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
Anti-CanAg (huC242)-Mal-dPEG4-NHS-DM1 ADC (ADC-008LCT)
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- Target: CanAg
- Linker: PEG4Mal
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
anti-MUC1 immunotoxin H23 (scFv)-PE (AGTO-L064E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
anti-MUC1 immunotoxin C242 (Fab)-PE (AGTO-L036E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
Anti-Human MUC1 Therapeutic Antibody (Sontuzumab) (TAB-H65)
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Anti-Human MUC1 Therapeutic Antibody (Pemtumomab) (TAB-H56)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Anti-Human MUC1 Therapeutic Antibody (Yttrium (90 Y) Clivatuzumab Tetraxetan) (TAB-H77)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, Inhib
Anti-Human MUC1 Therapeutic Antibody Fab Fragment (Clivatuzumab Tetraxetan) (TAB-037-F(E))
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab - G1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Recombinant Anti-human MUC1 VHH Single Domain Antibody (NAB-2049-VHH)
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- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, IP, ChiP, Neut, ELISA
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