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Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) (CAT#: Gly-012LC)

This product is a humanized monoclonal antibody with N-glycosylation sites at CDR2 of VH. The glycosylation in CDR2 increased the half-life of the antibody. hPM specifically binds human MUC1 and can be potentially used in the treatment of ovarian cancer.


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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RPTEC TERT1
Figure 1 IF staining of human cell line RPTEC TERT1
(Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/1789_B9_13_cr596f381e20667_selected.jpg
Figure 2 IHC staining of human stomach
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1986/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/100_E7_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/101_E7_1_blue_red_green.jpg
Normal Tissue
Figure 5 Stomach
Figure 5 Stomach
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_2_1.jpg
Figure 6 Colon
Figure 6 Colon
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_9_3.jpg
Figure 7 Kidney
Figure 7 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_8_5.jpg
Figure 8 Testis
Figure 8 Testis
(Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185499-MUC1

Glyco-engineering

  • Glycosylation site
  • CDR2 of VH
  • Glycosylation Type
  • N-glycosylation
  • Activity
  • Increased half-life

Specifications

  • Target
  • MUC1 (Mucin 1)
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Antibody Isotype
  • IgG
  • Clone
  • hPM (humanized Pankomab)
  • Expression Host
  • GT-5s (Fuc+)
  • Applications
  • ELISA, FC, IHC

Target

  • Alternative Names
  • MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-
  • Related Disease
  • Ovarian cancer

Downloads

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Single-domain Antibody

CAT Product Name Application Type
NAB-2049-VHH Recombinant Anti-human MUC1 VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH
HPAB-AP504-YC Recombinant Camel Anti-MUC1 Single Domain Antibody (5-24) FC Camel VHH
HPAB-AP505-YC Recombinant Camel Anti-MUC1 Single Domain Antibody (aMUC1) ELISA Camel VHH
HPAB-0736-YJ-VHH Camelid Anti-MUC1 Recombinant Single Domain Antibody (ER46) ELISA Camelid VHH
HPAB-0737-YJ-VHH Camelid Anti-MUC1 Recombinant Single Domain Antibody (AR-32) ELISA Camelid VHH

Humanized Antibody

CAT Product Name Application Type
TAB-173 Anti-Human MUC1 Recombinant Antibody (Cantuzumab Ravtansine) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1 - kappa
TAB-166 Humanized Anti-MUC1 Recombinant Antibody (clone Cantuzumab) IP, IF, FuncS, FC, Neut, ELISA, ICC Humanized (from mouse) IgG1, κ
TAB-037-F(E) Anti-Human MUC1 Recombinant Antibody Fab Fragment (Clivatuzumab Tetraxetan) Neut, ELISA, IF, IP, FuncS, FC, IHC Fab - G1 - kappa
TAB-H77 Human Anti-MUC1 Recombinant Antibody (TAB-H77) FuncS, Inhib IgG1, κ
TAB-026ML Anti-Human MUC1 Recombinant Antibody (Gatipotuzumab) ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

Mouse Antibody

CAT Product Name Application Type
TAB-765 Mouse Anti-MUC1 Recombinant Antibody (clone Nacolomab); Fab Fragment FC, IP, ELISA, Neut, FuncS, IF, ICC Mouse Fab (IgG1, κ)
TAB-411MZ-S(P) Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-411MZ-S(P)) ELISA Mouse scFv
PABX-183 Recombinant Mouse Anti-MUC1 Antibody (CTM01) Neut, FuncS IgG
PABX-183-S (P) Recombinant Mouse Anti-MUC1 Antibody scFv Fragment (CTM01) Neut, FuncS scFv
PABX-183-F (E) Recombinant Mouse Anti-MUC1 Antibody Fab Fragment (CTM01) Neut, FuncS Fab

Immunotoxin

CAT Product Name Application Type
AGTO-L036E anti-MUC1 immunotoxin C242 (Fab)-PE Cytotoxicity assay, Functional assay
AGTO-L064E anti-MUC1 immunotoxin H23 (scFv)-PE Cytotoxicity assay, Functional assay

Chimeric Antibody

CAT Product Name Application Type
TAB-412MZ Human Anti-MUC1 Recombinant Antibody (TAB-412MZ) ELISA Chimeric (mouse/human) IgG
TAB-412MZ-S(P) Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-412MZ-S(P)) ELISA Mouse scFv
TAB-412MZ-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-412MZ-F(E)) ELISA Chimeric (mouse/human) Fab

Human Antibody

CAT Product Name Application Type
TAB-431MZ-F(E) Anti-Human MUC1 Recombinant Antibody Fab Fragment (PH1) ELISA, WB, FC, IHC Human antibody
TAB-432MZ-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-432MZ-F(E)) ELISA, FC Human Fab
TAB-433MZ-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-433MZ-F(E)) ELISA, FC Human Fab
TAB-434MZ-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-434MZ-F(E)) ELISA, FC Human Fab
PABX-143-S (P) Recombinant Human Anti-MUC1 Antibody scFv Fragment (CTM01) WB, ELISA, FuncS scFv

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-012LC-1 Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-109LC Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) ELISA Human antibody

Fab Glycosylation

CAT Product Name Application Type
Gly-120LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) ELISA Mouse antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-121LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody
Gly-122LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody
Gly-123LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody
Gly-124LC Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) ELISA Mouse antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0379MZ Chicken Anti-MUC1 Polyclonal IgY IHC, WB Chicken antibody

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC096 PE-A*02:01/Human MUC1 (LLLLTVLTV) MHC Tetramer FCM
MHC-LC097 APC-A*02:01/Human MUC1 (LLLLTVLTV) MHC Tetramer FCM
MHC-LC781 A*0201/Human MUC-1 (LLLLTVLTV) MHC Tetramer FCM
MHC-LC1950 PE-A2/Human MUC1 (NLTISDVSV) MHC Tetramer FCM
MHC-YF570 A*02:01/Human Mucin (TLAPATEPA) MHC Pentamer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2320 Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) IHC-P, IHC-Fr IgG

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0838LC Recombinant Mouse Anti-Human MUC1 Antibody (SM3) ELISA IgG1
EPAF-0581CQ Recombinant Mouse Anti-Human MUC1 Antibody (B27.29) Neut, FC IgG1
EPAF-0583CQ Recombinant Mouse Anti-Human MUC1 Antibody (BC4E549) Neut, FC IgG1
EPAF-0584CQ Recombinant Mouse Anti-Human MUC1 Antibody (DF3) Neut, FC IgG1

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0091-YC-F(E) Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0091-YC-F(E)) ELISA, Neut Mouse Fab
HPAB-0094-YC-F(E) Mouse Anti-MUC1 Recombinant Antibody (clone 12D10); Fab Fragment ELISA, FC Mouse Fab
HPAB-0872LY-F(E) Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0872LY-F(E)) ELISA, WB, FC Mouse Fab
HPAB-0873LY-F(E) Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0873LY-F(E)) ELISA, WB, FC Humanized Fab
HPAB-0874LY-F(E) Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0874LY-F(E)) ELISA, WB, FC Mouse Fab

Recombinant Antibody

CAT Product Name Application Type
HPAB-0272CQ Human Anti-MUC1 Recombinant Antibody (HPAB-0272CQ) ELISA, FC, FuncS Human IgG1, κ
PABC-399 Mouse Anti-MUC1 Recombinant Antibody (clone AR20.5) ELISA, FC, FuncS Mouse IgG1
PABC-400 Mouse Anti-MUC1 Recombinant Antibody (clone SM3) FC, IHC-Fr, IF, ELISA, IHC-P Mouse IgG1
HPAB-AP738-YC Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP738-YC) ELISA Mouse IgG
HPAB-AP739-YC Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP739-YC) ELISA Mouse IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0272CQ-S(P) Human Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0272CQ-S(P)) ELISA, FC, FuncS Human scFv
HPAB-0872LY-S(P) Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0872LY-S(P)) ELISA, WB, FC Mouse scFv
HPAB-0873LY-S(P) Human Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0873LY-S(P)) ELISA, WB, FC Human scFv
HPAB-0207-YJ-S(P) Human Anti-MUC1 Recombinant Antibody (clone Clivatuzumab (hPAM4)); scFv Fragment ELISA, IHC, FuncS Humanized scFv
FAMAB-0211JF-S(P) Human Anti-MUC1 Recombinant Antibody (clone G8); scFv Fragment ELISA, FuncS Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H56 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Pemtumomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-H65 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Sontuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-026ML Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-166 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Cantuzumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-H77 Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) ELISA, FC, IP, FuncS, IF IgG1, κ

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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