Anti-CD37-vc-MMAE ADC
CAT#: ADC-037LZY
This ADC product is composed of an anti-CD37 antibody conjugated via vc linker to MMAE (anti-CD37-vc-MMAE). It is in Phase I clinical trials and has demonstrated a response in Lymphoid malignancies treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37
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Specifications
- Antibody Overview
- Human Anti-CD37 IgG2
- Antibody Isotype
- IgG2
- Linker
- VC (Valine-citrulline)
- Linker Class/Description
- Class: peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD37; CD37 molecule; GP52-40; TSPAN26; leukocyte antigen CD37; tspan-26; tetraspanin-26; leukocyte surface antigen CD37; cell differentiation antigen 37;
- Gene ID
- 951
- UniProt ID
- P11049
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Datasheet
MSDS
COA
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|---|---|---|---|
| MOB-1367z | Mouse Anti-CD37 Recombinant Antibody (clone 41C4) | WB, IP, IF, IHC, ELISA | Mouse IgG2b, κ |
| HPAB-AP033-YC | Human Anti-CD37 Recombinant Antibody (clone A2) | FuncS | Human IgG |
| HPAB-AP034-YC | Human Anti-CD37 Recombinant Antibody (clone B2) | FuncS | Human IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0272CL | Human Anti-CD37 Recombinant Antibody (TAB-0272CL) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL | Human Anti-CD37 Recombinant Antibody (TAB-0273CL) | Block | Chimeric (mouse/human) |
| TAB-0272CL-S(P) | Human Anti-CD37 Recombinant Antibody scFv Fragment (TAB-0272CL-S(P)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0272CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0272CL-F(E)) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL-F(E) | Human Anti-CD37 Recombinant Antibody Fab Fragment (TAB-0273CL-F(E)) | Block | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467CQ | Anti-Human CD37 Recombinant Antibody (Lilotomab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0159-FY-F(E)) | Activ, Depletion, FuncS, Inhib | Mouse Fab |
| HPAB-0163-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0163-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-0164-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0164-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-AP033-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment | FuncS | Human Fab |
| HPAB-AP034-YC-F(E) | Human Anti-CD37 Recombinant Antibody (clone B2); Fab Fragment | FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-467CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1045-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1045-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1046-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1046-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1047-FY-F(E) | Human Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-1047-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-0004-SJF-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0004-SJF-S(P)) | ELISA, IHC, FuncS | Mouse scFv |
| HPAB-0006-SJF-S(P) | Mouse Anti-CD37 Recombinant Antibody (clone A0); scFv Fragment | FACS, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC112 | Mouse Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC112), CDC Enhanced | FC, Inhib, CDC | Antibody hexamer |
| VS-0924-YC113 | Human Anti-CD37 Recombinant Antibody Hexamer (VS-0924-YC113), CDC Enhanced | CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY21 | Human Anti-CD37 (clone chHH1.1) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY43 | CytoStream™ Mouse Anti-CD37 Recombinant Antibody (VS-0225-XY43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC73 | Recombinant Anti-CD37 Vesicular Antibody, EV Displayed (VS-0425-YC73) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC9 | Recombinant Anti-CD37 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
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