Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb

Name: Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb
SKU: VS-0525-YC2
Rating: 5 (1 reviews)

CAT#: VS-0525-YC2

This biparatopic antibody (bpAb) is a half-life extended tandem sdAb designed to target two independent amyloid-beta epitopes, Aβ40 and Aβ42, with high affinity. It is intended for research on Alzheimer's disease.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

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Specifications

Host Animal 1
Human

Host Animal 2
Human

Specificity
Human APP

Species Reactivity
Human

Type
Tandem sdAb

Valency
1 + 1

Epitope 1
Aβ40

Epitope 2
Aβ42

Purity
>90%

Purification
Affinity purified

Applications
ELISA, Inhib

Concentration
Lot specific

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

Long Name
Amyloid Beta Precursor Protein

Target

Introduction
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Alternative Names
AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma

Gene ID
351

UniProt ID
P05067

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Downloadable Resources

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Datasheet

Datasheet - VS-0525-YC2.pdf

MSDS

MSDS - VS-0525-YC2.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
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TAB-0019CL-VHH	Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH)	IHC, WB	Camelid VHH
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NS-001CN	Human Anti-APP Recombinant Antibody (clone AS)	WB	Human IgG
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NS-007CN-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E))	ELISA	Mouse Fab
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HPAB-0116CQ-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0116CQ-S(P))	ELISA, WB, IP, FuncS	Mouse scFv
HPAB-0117CQ-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0117CQ-S(P))	ELISA, WB, IP, FuncS	Human scFv
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