Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab)

Name: Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab)
SKU: VS-0525-YC198
Rating: 5 (1 reviews)

CAT#: VS-0525-YC198

Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab) is a biparatopic antibody (bpAb) engineered to bind two distinct APP epitopes. This molecule employs a tandem scFv format. Its construction involved N-terminally fusing the Solanezumab scFv (targeting amyloid β 13-28) to the Ponezumab scFv (specific for amyloid β 33-40).

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

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Specifications

Host Animal 1
Mouse

Host Animal 2
Mouse

Specificity
Human APP

Species Reactivity
Human

Type
Tandem scFv

Valency
1 + 1

Clone 1
Solanezumab

Clone 2
Ponezumab

Epitope 1
Amyloid β 13-28

Epitope 2
Amyloid β 33-40

Purity
>90%

Purification
Affinity purified

Applications
ELISA, FC, IF, IP, Neut, WB

Concentration
Lot specific

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

Long Name
Amyloid Beta Precursor Protein

Target

Introduction
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.

Alternative Names
APP; amyloid beta (A4) precursor protein; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide

Gene ID
351

UniProt ID
P05067

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Downloadable Resources

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Datasheet

Datasheet - VS-0525-YC198.pdf

MSDS

MSDS - VS-0525-YC198.pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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