Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab) (CAT#: VS-0525-YC198)

• Host Animal 1
• Mouse

• Host Animal 2
• Mouse

• Specificity
• Human APP

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• Solanezumab

• Clone 2
• Ponezumab

• Epitope 1
• Amyloid β 13-28

• Epitope 2
• Amyloid β 33-40

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC, IF, IP, Neut, WB

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Amyloid Beta Precursor Protein

• Introduction
• Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.

• Alternative Names
• APP; amyloid beta (A4) precursor protein; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide

• Gene ID
• 351

• UniProt ID
• P05067

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