Recombinant Anti-APP (AA 3-7 x AA 12-28) Biparatopic Antibody, Tandem scFv (Clone h12A11v1 x Solanezumab)
CAT#: VS-0525-YC18
The recombinant Anti-APP (AA 3-7 x AA 12-28) biparatopic antibody, tandem scFv (Clone h12A11v1 x Solanezumab) binds two different epitopes on the APP protein. This antibody is constructed with the h12A11v1 scFv targeting the Aβ 3-7 region and is fused at the N-terminus to the Solanezumab scFv, which targets the Aβ 12-28 region.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Mouse
- Specificity
- Human APP
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- h12A11v1
- Clone 2
- Solanezumab
- Epitope 1
- Aβ 3-7
- Epitope 2
- Aβ 12-28
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, Neut, FC, IF, IP, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Amyloid Beta Precursor Protein
Target
- Introduction
- This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
- Alternative Names
- Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein;
- Gene ID
- 351
- UniProt ID
- P05067
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
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| TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
| TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH) | ELISA, IHC | Single domain antibody |
| TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH) | ELISA, In vivo, FuncS | Single domain antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-254CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P)) | ELISA | Mouse scFv |
| TAB-0789CLV | Human Anti-APP Recombinant Antibody (TAB-0789CLV) | IP | Chimeric (mouse/human) IgG |
| TAB-0789CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0789CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0802CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-252CQ-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-252CQ-F(E)) | ELISA | Mouse Fab |
| TAB-255CQ-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-255CQ-F(E)) | ELISA | Mouse Fab |
| TAB-0772CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0772CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0773CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0773CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0774CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0774CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0783CLV | Human Anti-APP Recombinant Antibody (TAB-0783CLV) | ELISA, FuncS | Human IgG |
| TAB-0784CLV | Human Anti-APP Recombinant Antibody (TAB-0784CLV) | ELISA | Human IgG |
| TAB-0785CLV | Human Anti-APP Recombinant Antibody (TAB-0785CLV) | ELISA | Human IgG |
| TAB-0786CLV | Human Anti-APP Recombinant Antibody (TAB-0786CLV) | ELISA | Human IgG |
| TAB-0801CLV | Anti-Human APP Recombinant Antibody (3H3) | IHC, FuncS | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
| CAT | Product Name | Application | Type |
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| PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
| PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
| MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
| MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
| MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
| EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
| EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
| EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
| EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
| NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
| NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
| NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
| NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0176-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0176-FY-F(E)) | AG | Mouse Fab, κ |
| HPAB-0525-WJ-F(E) | Human Anti-APP Recombinant Antibody (clone h12A11); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0346-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone IBL-102); Fab Fragment | Cyt, WB, ELISA | Mouse Fab |
| HPAB-1640-FY-S(P) | Human Anti-APP Recombinant Antibody (clone 266); Fab Fragment | Cyt | Humanized Fab |
| HPAB-1641-FY-S(P) | Mouse Anti-APP Recombinant Antibody scFv Fragment (HPAB-1641-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0116CQ | Mouse Anti-APP Recombinant Antibody (HPAB-0116CQ) | ELISA, WB, IP, FuncS | Mouse IgG1, κ |
| HPAB-0117CQ | Human Anti-APP Recombinant Antibody (HPAB-0117CQ) | ELISA, WB, IP, FuncS | Human IgG1, κ |
| HPAB-0118CQ | Human Anti-APP Recombinant Antibody (clone Fv1E4) | ELISA, Inhib | Human IgG |
| HPAB-0119CQ | Human Anti-APP Recombinant Antibody (clone h12A11v1) | ELISA, CFC, FuncS | Human IgG1 |
| HPAB-0120CQ | Human Anti-APP Recombinant Antibody (HPAB-0120CQ) | ELISA, IHC, FuncS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-225) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-228) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-229) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-226) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0008-YJ | Mouse Anti-APP Recombinant Antibody (clone 508F) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0525-WJ-S(P) | Human Anti-APP Recombinant Antibody (clone h12A11); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0970-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0970-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0971-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0971-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0973-FY-F(E) | Human Anti-APP Recombinant Antibody (clone E12); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0974-FY-F(E) | Human Anti-APP Recombinant Antibody (clone 1C10); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY17 | AbPlus™ Anti-APP Magnetic Beads (DE2B4) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY23 | Mouse Anti-NHP APP Recombinant Antibody (VS-1024-XY23) | WB, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY6 | Human Anti-APP (clone 2A7) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC204 | Recombinant Anti-APP Vesicular Antibody, EV Displayed (VS-0425-YC204) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY469 | Anti-APP Immunohistochemistry Kit | IHC | |
| VS-0525-XY470 | Anti-Mouse APP Immunohistochemistry Kit | IHC | |
| VS-0525-XY471 | Anti-Monkey APP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC2 | Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb | ELISA, Inhib | Tandem sdAb |
| VS-0525-YC196 | Recombinant Anti-APP (AA 1-5 x AA 13-28) Biparatopic Antibody, Tandem scFv | ELISA, FC, IF, IP, Neut, WB | Tandem scFv |
| VS-0525-YC198 | Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab) | ELISA, FC, IF, IP, Neut, WB | Tandem scFv |
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