AbPlus™ Anti-APP Magnetic Beads (DE2B4)
CAT#: VS-0424-XY17
The AbPlus Anti-APP Magnetic Beads (DE2B4) is an innovative affinity resin which is bound with anti-APP specific antibody (DE2B4). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of APP protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-APP specific antibody (DE2B4)
- Target
- APP
- Immunogen
- Synthetic peptide of human amyloid beta protein, AA 1-16.
- Target Species
- Human, Pig, Cow. Does not cross react with Mouse or Rat.
- Antibody Clone
- DE2B4
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
- Alternative Names
- AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP; amyloid-beta precursor protein; alzheimer disease amyloid A4 protein homolog alzheimer disease amyloid protein amyloid beta (A4) precursor protein amyloid beta A4 protein amyloid precursor protein beta-amyloid peptide beta-amyloid peptide(1-40) beta-amyloid peptide(1-42) beta-amyloid precursor protein cerebral vascular amyloid peptide peptidase nexin-II protease nexin-II testicular tissue protein Li 2
- Gene ID
- 351
- UniProt ID
- P05067
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| TAB-0802CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
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| MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
| EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
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| CAT | Product Name | Application | Type |
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| NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
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| NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
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| AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-228) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-229) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-226) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0008-YJ | Mouse Anti-APP Recombinant Antibody (clone 508F) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0525-WJ-S(P) | Human Anti-APP Recombinant Antibody (clone h12A11); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0970-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0970-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0971-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0971-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0973-FY-F(E) | Human Anti-APP Recombinant Antibody (clone E12); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0974-FY-F(E) | Human Anti-APP Recombinant Antibody (clone 1C10); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0970-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0970-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0971-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0971-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0973-FY-S(P) | Human Anti-APP Recombinant Antibody (clone E12); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0974-FY-S(P) | Human Anti-APP Recombinant Antibody (clone 1C10); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0975-FY-S(P) | Human Anti-APP Recombinant Antibody (clone 4D3); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY23 | Mouse Anti-NHP APP Recombinant Antibody (VS-1024-XY23) | WB, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY6 | Human Anti-APP (clone 2A7) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC204 | Recombinant Anti-APP Vesicular Antibody, EV Displayed (VS-0425-YC204) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY469 | Anti-APP Immunohistochemistry Kit | IHC | |
| VS-0525-XY470 | Anti-Mouse APP Immunohistochemistry Kit | IHC | |
| VS-0525-XY471 | Anti-Monkey APP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC2 | Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb | ELISA, Inhib | Tandem sdAb |
| VS-0525-YC18 | Recombinant Anti-APP (AA 3-7 x AA 12-28) Biparatopic Antibody, Tandem scFv (Clone h12A11v1 x Solanezumab) | ELISA, Neut, FC, IF, IP, WB | Tandem scFv |
| VS-0525-YC196 | Recombinant Anti-APP (AA 1-5 x AA 13-28) Biparatopic Antibody, Tandem scFv | ELISA, FC, IF, IP, Neut, WB | Tandem scFv |
| VS-0525-YC198 | Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab) | ELISA, FC, IF, IP, Neut, WB | Tandem scFv |
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