Human Anti-APP (clone 2A7) scFv-Fc Chimera
CAT#: VS-0325-FY6
Anti-APP scFv-Fc is a single-chain variable fragment (scFv) of an antibody that binds to amyloid precursor protein (APP). The scFv-Fc format is a fusion of an scFv with the Fc region of an immunoglobulin G (IgG) antibody. Anti-APP scFv-Fc antibodies can be used in research and therapy. For example, anti-APP scFv-Fc antibodies could be used to treat diseases associated with amyloid oligomers, such as Alzheimer's disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human APP
- Species Reactivity
- Human
- Clone
- 2A7
- Applications
- ELISA
- Related Disease
- Alzheimer's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein
- Gene ID
- 351
- UniProt ID
- P05067
- Long Name
- Amyloid Beta Precursor Protein
- Sequence Similarities
- Belongs to the APP family.
- Cellular Localization
- Cell membrane; Membrane; Perikaryon; Cell projection, growth cone; Membrane, clathrin-coated pit; Early endosome; Cytoplasmic vesicle
- Post Translation Modifications
- Proteolytically processed under normal cellular conditions.
Proteolytically cleaved by caspases during neuronal apoptosis.
N-glycosylated
Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific
Extracellular binding and reduction of copper, results in a corresponding oxidation of Cys-144 and Cys-158, and the formation of a disulfide bond.
Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP.
Amyloid-beta peptides are degraded by IDE.
Sulfated on tyrosine residues.
Glycosylation at Thr107, Thr381, Thr352, Thr353, Thr366, Thr367, Ser370, Thr371, Asn542, Asn571, Thr600, Thr633, Thr651, Thr652, Ser656, Thr659, Thr663, Ser667, and Tyr681
Ubiquitination at Lys751 and Lys763
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 26 sites, 4 N-linked glycans (1 site), 5 O-linked glycans (22 sites)
- Protein Refseq
- NP_000475.1; NP_001129488.1; NP_001129601.1; NP_001129602.1; NP_001129603.1
- Function
- Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
Interaction between APP molecules on neighboring cells promotes synaptogenesis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| TAB-0344CL-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0344CL-F(E)) | ELISA, FuncS, In vivo | Human Fab |
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| TAB-254CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P)) | ELISA | Mouse scFv |
| TAB-254CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0789CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0789CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-0789CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P)) | ELISA | Mouse scFv |
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| MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
| MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
| MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
| EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
| EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
| EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
| EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
| NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
| NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
| NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
| NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0116CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0116CQ-S(P)) | ELISA, WB, IP, FuncS | Mouse scFv |
| HPAB-0117CQ-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0117CQ-S(P)) | ELISA, WB, IP, FuncS | Human scFv |
| HPAB-0118CQ-S(P) | Human Anti-APP Recombinant Antibody (clone Fv1E4); scFv Fragment | ELISA, Inhib | Human scFv |
| HPAB-0119CQ-S(P) | Human Anti-APP Recombinant Antibody (clone h12A11v1); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-0120CQ-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0120CQ-S(P)) | ELISA, IHC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-394 | Mouse Anti-APP Recombinant Antibody (clone c#6); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| PFBC-395 | Mouse Anti-APP Recombinant Antibody (clone c#24); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| HPAB-0255-YJ-F(E) | Human Anti-APP Recombinant Antibody (clone CBA45YJ); Fab Fragment | ELISA, WB, Inhib, FuncS | Human Fab |
| HPAB-0970-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0970-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0971-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0971-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0241-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0241-FY) | Inhib, FuncS | Mouse IgG1 |
| HPAB-0242-FY | Human Anti-APP Recombinant Antibody (HPAB-0242-FY) | WB | Humanized IgG1 |
| HPAB-0970-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY) | ELISA | Mouse IgG |
| HPAB-0971-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0971-FY) | ELISA | Mouse IgG |
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|---|---|---|---|
| AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-225) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-228) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-229) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-226) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0008-YJ | Mouse Anti-APP Recombinant Antibody (clone 508F) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY17 | AbPlus™ Anti-APP Magnetic Beads (DE2B4) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY23 | Mouse Anti-NHP APP Recombinant Antibody (VS-1024-XY23) | WB, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC204 | Recombinant Anti-APP Vesicular Antibody, EV Displayed (VS-0425-YC204) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY469 | Anti-APP Immunohistochemistry Kit | IHC | |
| VS-0525-XY470 | Anti-Mouse APP Immunohistochemistry Kit | IHC | |
| VS-0525-XY471 | Anti-Monkey APP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC2 | Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb | ELISA, Inhib | Tandem sdAb |
| VS-0525-YC18 | Recombinant Anti-APP (AA 3-7 x AA 12-28) Biparatopic Antibody, Tandem scFv (Clone h12A11v1 x Solanezumab) | ELISA, Neut, FC, IF, IP, WB | Tandem scFv |
| VS-0525-YC196 | Recombinant Anti-APP (AA 1-5 x AA 13-28) Biparatopic Antibody, Tandem scFv | ELISA, FC, IF, IP, Neut, WB | Tandem scFv |
| VS-0525-YC198 | Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab) | ELISA, FC, IF, IP, Neut, WB | Tandem scFv |
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