Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227)

Name: Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227)
SKU: AFC-TAB-227
Rating: 5 (1 reviews)

CAT#: AFC-TAB-227

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Abeta. It is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
ELISA, IP, FC, FuncS, Neut

Conjugate
Unconjugated

Generic Name
Ponezumab

Related Disease
Alzheimer's disease (AD)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid p

Gene ID
351

UniProt ID
P05067

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Biosimilar Overview

Please refer to Ponezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ponezumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-227.pdf

MSDS

MSDS - AFC-TAB-227.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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See other products for "Ponezumab"

Anti-Human Abeta Recombinant Antibody (Ponezumab)
Recombinant monoclonal antibody to Abeta. Ponezumab is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.

See other products for "APP"

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CAT	Product Name	Application	Type
PFBL-010	Mouse Anti-APP Recombinant Antibody (clone 12A11); Fab Fragment	WB, IF, FuncS	Mouse Fab
PFBL-011	Mouse Anti-APP Recombinant Antibody (clone 3D6); Fab Fragment	WB, ELISA, FuncS	Mouse Fab
PFBL-012	Human Anti-APP Recombinant Antibody (clone 9TL); Fab Fragment	WB, FuncS	Human Fab
PFBL-013	Mouse Anti-APP Recombinant Antibody (clone C705); Fab Fragment	WB, ELISA, FuncS	Mouse Fab
PFBC-527	Mouse Anti-APP Recombinant Antibody (clone c#17); Fab Fragment	ELISA, WB, FuncS	Mouse Fab

CAT	Product Name	Application	Type
PNBL-004	Recombinant Anti-Human APP VHH Single Domain Antibody (PNBL-004)	WB, ELISA, FuncS	Llama VHH
PNBL-070	Recombinant Anti-APP VHH Single Domain Antibody (PNBL-070)	ELISA, Neut, WB, Inhibition	Llama VHH
TAB-0019CL-VHH	Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH)	IHC, WB	Camelid VHH
TAB-0020CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH)	ELISA, IHC	Single domain antibody
TAB-0021CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH)	ELISA, In vivo, FuncS	Single domain antibody

CAT	Product Name	Application	Type
TAB-0343CL-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0343CL-F(E))	ELISA, FuncS, In vivo	Human Fab
TAB-0344CL-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0344CL-F(E))	ELISA, FuncS, In vivo	Human Fab
TAB-0783CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0783CLV-S(P))	ELISA, FuncS	Human scFv
TAB-0784CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0784CLV-S(P))	ELISA	Human scFv
TAB-0785CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0785CLV-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-253CQ	Human Anti-APP Recombinant Antibody (TAB-253CQ)	ELISA	Humanized IgG1
TAB-0790CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0790CLV-S(P))	ELISA	Humanized scFv
TAB-0828CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0828CLV-S(P))	ELISA	Mouse scFv
TAB-0829CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0829CLV-S(P))	ELISA	Mouse scFv
TAB-0830CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0830CLV-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-254CQ	Human Anti-APP Recombinant Antibody (TAB-254CQ)	ELISA	Chimeric (mouse/human) IgG1
TAB-254CQ-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-0802CLV-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-0789CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P))	ELISA	Mouse scFv
TAB-0802CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0802CLV-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-0772CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0772CLV-S(P))	ELISA	Mouse scFv
TAB-0773CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0773CLV-S(P))	ELISA	Mouse scFv
TAB-0774CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0774CLV-S(P))	ELISA	Mouse scFv
TAB-0775CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0775CLV-S(P))	ELISA	Mouse scFv
TAB-0776CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0776CLV-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
BRD-0685MZ	Chicken Anti-APP Polyclonal IgY	IHC	Chicken antibody

CAT	Product Name	Application	Type
PABX-014	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204)	WB, ELISA, FuncS	Rabbit IgG
PABX-014-F (E)	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment	WB, ELISA, FuncS	Rabbit Fab
MOR-0220	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB)	ELISA, WB	Rabbit IgG
MOR-4539	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS)	IHC-P, ELISA	Rabbit IgG
MOR-0082-FY	Rabbit Anti-APP Recombinant Antibody (clone AFY0053)	ICC, IHC-P, WB	Rabbit IgG

CAT	Product Name	Application	Type
EPAF-0566CQ	Mouse Anti-APP Recombinant Antibody (clone 6E10)	ELISA	Mouse IgG
EPAF-0567CQ	Mouse Anti-APP Recombinant Antibody (clone 4G8)	ELISA, IHC	Mouse IgG2b
EPAF-0568CQ	Human Anti-APP Recombinant Antibody (clone HyL5)	ELISA, Inhib	Human IgM
EPAF-0569CQ	Mouse Anti-APP Recombinant Antibody (clone AB1-42)	IHC	Mouse IgG
EPAF-0570CQ	Human Anti-APP Recombinant Antibody (clone L11.3)	IHC, ELISA, Inhib	Human IgM

CAT	Product Name	Application	Type
NS-001CN	Human Anti-APP Recombinant Antibody (clone AS)	WB	Human IgG
NS-007CN	Mouse Anti-APP Recombinant Antibody (NS-007CN)	ELISA, FuncS	Mouse IgG1
NS-001CN-F(E)	Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment	WB	Human Fab
NS-007CN-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E))	ELISA	Mouse Fab
NS-001CN-S(P)	Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment	WB	Human scFv

CAT	Product Name	Application	Type
HPAB-0176-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0176-FY)	AG	Mouse IgG1, κ
MRO-1647-CN	Rabbit Anti-APP Polyclonal Antibody (MRO-1647-CN)	WB, IF, IHC, FC	Rabbit IgG
HPAB-0970-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY)	ELISA	Mouse IgG
HPAB-0971-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0971-FY)	ELISA	Mouse IgG
HPAB-0973-FY	Human Anti-APP Recombinant Antibody (clone E12)	ELISA	Humanized IgG

CAT	Product Name	Application	Type
PSBC-527	Mouse Anti-APP Recombinant Antibody (clone c#17); scFv Fragment	ELISA, WB, FuncS	Mouse scFv
HPAB-0525-WJ-S(P)	Human Anti-APP Recombinant Antibody (clone h12A11); scFv Fragment	ELISA	Humanized scFv
HPAB-0970-FY-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0970-FY-F(E))	ELISA	Mouse Fab
HPAB-0971-FY-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0971-FY-F(E))	ELISA	Mouse Fab
HPAB-0973-FY-F(E)	Human Anti-APP Recombinant Antibody (clone E12); scFv Fragment	ELISA	Humanized scFv

CAT	Product Name	Application	Type
AFC-TAB-225	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-225)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-228	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-228)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-229	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-229)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-226	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-226)	IF, IP, Neut, FuncS, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-0008-YJ	Mouse Anti-APP Recombinant Antibody (clone 508F)	ELISA	Mouse IgM

CAT	Product Name	Application	Type
VS-0424-XY17	AbPlus™ Anti-APP Magnetic Beads (DE2B4)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-1024-XY23	Mouse Anti-NHP APP Recombinant Antibody (VS-1024-XY23)	WB, ICC	Mouse IgG1

CAT	Product Name	Application	Type
VS-0325-FY6	Human Anti-APP (clone 2A7) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC204	Recombinant Anti-APP Vesicular Antibody, EV Displayed (VS-0425-YC204)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application
VS-0525-XY469	Anti-APP Immunohistochemistry Kit	IHC
VS-0525-XY470	Anti-Mouse APP Immunohistochemistry Kit	IHC
VS-0525-XY471	Anti-Monkey APP Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC2	Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb	ELISA, Inhib	Tandem sdAb
VS-0525-YC18	Recombinant Anti-APP (AA 3-7 x AA 12-28) Biparatopic Antibody, Tandem scFv (Clone h12A11v1 x Solanezumab)	ELISA, Neut, FC, IF, IP, WB	Tandem scFv
VS-0525-YC196	Recombinant Anti-APP (AA 1-5 x AA 13-28) Biparatopic Antibody, Tandem scFv	ELISA, FC, IF, IP, Neut, WB	Tandem scFv
VS-0525-YC198	Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab)	ELISA, FC, IF, IP, Neut, WB	Tandem scFv

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