Anti-AXL Antibody Prodrug, Protease Activated (VS-1025-YC64)
CAT#: VS-1025-YC64
The Anti-AXL Antibody Prodrug, Protease Activated (VS-1025-YC64) is an antibody prodrug comprised of a recombinant human antibody targeting human AXL, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to AXL protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to AXL effectively. AXL is a receptor tyrosine kinase that, when overexpressed or hyperactivated, promotes tumor progression by increasing cell survival, motility, and invasion. Its activation in various solid tumors is primarily associated with conferring resistance to targeted therapies (like EGFR and HER2 inhibitors). Thus, AXL inhibitors are being developed to circumvent drug resistance.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, actin filaments & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75217/1899_C1_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human thyroid gland
Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32501/ihc_selected.jpg
Normal Tissue
Figure 3 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_B_1_6.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167601-AXL
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human AXL
- Target
- AXL
- Species Reactivity
- Human, Mouse
- Isotype
- IgG
- Epitope
- AA 1-134
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.
- Alternative Names
- ARK; UFO; JTK11; Tyro7
- Gene ID
- 558
- UniProt ID
- P30530
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2240z | Mouse Anti-AXL Recombinant Antibody (clone 23F11) | WB, ELISA, IF, IHC | Mouse IgG1 |
| MOB-0872MZ | Mouse Anti-AXL Recombinant Antibody (clone 1B3A2) | WB | Mouse IgG1 |
| HPAB-0600-CN | Human Anti-AXL Recombinant Antibody (HPAB-0600-CN) | SPR, ELISA, FC, WB, Inhib, FuncS, IHC, Block | Human IgG |
| HPAB-0601-CN | Human Anti-AXL Recombinant Antibody (HPAB-0601-CN) | ELISA, FC, IHC, Block | Human IgG |
| HPAB-0603-CN | Human Anti-AXL Recombinant Antibody (HPAB-0603-CN) | WB, ELISA, FC, IHC | Chimeric (Mouse/Human) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0138CL | Mouse Anti-AXL Recombinant Antibody (TAB-0138CL) | ELISA, IF, FC, Inhib, ICFC | |
| TAB-0188CL | Mouse Anti-AXL Recombinant Antibody (TAB-0188CL) | ELISA | Mouse IgG |
| TAB-0335CL | Anti-Human AXL Recombinant Antibody (Ax225 (was demonstrated to recognize FND1 of AXL)) | WB, FuncS, ELISA | |
| TAB-0336CL | Anti-Human AXL Recombinant Antibody | WB, FuncS, ELISA | |
| TAB-1087CL | Human Anti-AXL Recombinant Antibody (TAB-1087CL) | ADCC | Chimeric (mouse/human) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0139CL | Anti-Human AXL Recombinant Antibody (hzl613F12-24 DAR2) | ELISA, IF, FC, Inhib, ICFC | Humanized Antibody |
| TAB-0140CL | Anti-Human AXL Recombinant Antibody (hzl613F12-33 DAR4) | ELISA, IF, FC, Inhib, ICFC | Humanized Antibody |
| TAB-1094CL | Anti-Human AXL Recombinant Antibody (Hz1613F12) | ELISA, FC, Cyt | Humanized antibody |
| TAB-1098CL | Anti-Human AXL Recombinant Antibody (Humanized 11B7) | ELISA, FuncS | Humanized antibody |
| TAB-1099CL | Anti-Human AXL Recombinant Antibody (Humanized 11D5) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0189CL | Human Anti-AXL Recombinant Antibody (TAB-0189CL) | WB, FuncS, ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
| TAB-1090CL | Human Anti-AXL Recombinant Antibody (TAB-1090CL) | ELISA, FuncS | Chimeric (mouse/human) IgG1, κ |
| TAB-1091CL | Human Anti-AXL Recombinant Antibody (TAB-1091CL) | ADCC | Chimeric (mouse/human) IgG1, κ |
| TAB-1092CL | Human Anti-AXL Recombinant Antibody (TAB-1092CL) | ADCC | Chimeric (mouse/human) IgG1, κ |
| TAB-0189CL-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (TAB-0189CL-S(P)) | WB, FuncS, ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3970 | Hi-Affi™ Rabbit Anti-AXL Recombinant Antibody (clone SI30DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0600-CN-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-0600-CN-S(P)) | ELISA, FC, IHC, Block | Human scFv |
| HPAB-0601-CN-S(P) | Human Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-0601-CN-S(P)) | ELISA, FC, IHC, Block | Human scFv |
| HPAB-0603-CN-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-0603-CN-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
| HPAB-0604-CN-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-0604-CN-S(P)) | ELISA, IHC | Mouse scFv |
| HPAB-0108-LS-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-0108-LS-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0600-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0600-CN-F(E)) | ELISA, FC, IHC, Block | Human Fab |
| HPAB-0601-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0601-CN-F(E)) | ELISA, FC, IHC, Block | Human Fab |
| HPAB-0603-CN-F(E) | Human Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0603-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
| HPAB-0604-CN-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0604-CN-F(E)) | ELISA, IHC | Mouse Fab |
| HPAB-0108-LS-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-0108-LS-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY26 | AbPlus™ Anti-AXL Magnetic Beads (VS-0424-XY26) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY44 | Rabbit Anti-NHP AXL Recombinant Antibody (VS-1024-XY44) | WB, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY2 | CytoStream™ Rat Anti-AXL Recombinant Antibody (clone 175128) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY66 | Human Anti-AXL (clone Enapotamab) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC363 | Recombinant Anti-AXL Vesicular Antibody, EV Displayed (VS-0425-YC363) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC20 | Recombinant Anti-AXL (AA 1-134 x AA 222-234) Biparatopic Antibody, Tandem scFv | Block, ELISA, FC, IHC, SPR, WB | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC218 | SmartAb™ Recombinant Anti-AXL pH-dependent Antibody (Clone Hz1613F12) | ELISA, FC, Cyt | Human IgG |
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