Human Anti-AXL (clone Enapotamab) scFv-Fc Chimera (CAT#: VS-0425-FY66)

• Immunogen
• Recombinant human AXL protein as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human AXL

• Species Reactivity
• Human

• Clone
• Enapotamab

• Applications
• ELISA

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 1/5000-1/10000
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• AXL Receptor Tyrosine Kinase; AXL Oncogene; EC 2.7.10.1; UFO; Tyrosine-Protein Kinase Receptor UFO; AXL Transforming Sequence/Gene

• Gene ID
• 558

• UniProt ID
• P30530

• Long Name
• AXL Receptor Tyrosine Kinase

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Monoubiquitinated upon GAS6-binding.
  A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.
  Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
  Glycosylation at Asn43, Asn157, Asn198, Asn339, Asn345, and Asn401
  Ubiquitination at Lys540
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect UFO_HUMAN (1983)
  Glycosylation from GlyGen 9 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)

• Protein Refseq
• NP_001265528.1; NP_001690.2; NP_068713.2

• Function
• Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation.
  Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL.
  Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11.
  Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2.
  Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.
  GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

• VS-0723-WK50
• Human Anti-AXL Recombinant Antibody (clone Enapotamab)

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