Recombinant Anti-AXL Vesicular Antibody, EV Displayed (VS-0425-YC363) (CAT#: VS-0425-YC363)

• Application
• ELISA, FC, Inhib, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• AXL

• Host Animal
• Mouse

• Antibody Isotype
• IgG

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• AXL receptor tyrosine kinase

• Biological Process
• Differentiation, Host-virus interaction, Immunity, Innate immunity

• Molecular Function
• Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Cellular Localization
• Plasma membrane, Vesicles, Actin filaments

• Introduction
• The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

• Alternative Names
• ARK, JTK11, Tyro7, UFO

• Gene ID
• 558

• UniProt ID
• P30530

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