Recombinant Anti-AXL Vesicular Antibody, EV Displayed (VS-0425-YC363)
CAT#: VS-0425-YC363
The Recombinant Anti-AXL Vesicular Antibody, EV Displayed (VS-0425-YC363) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to AXL-expressed cells or tissues. The AXL is a receptor tyrosine kinase contributing to cell growth and survival, with ligand-binding roles in inflammation and migration.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, actin filaments & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75217/1899_C1_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human thyroid gland
Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32501/ihc_selected.jpg
Normal Tissue
Figure 3 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_B_1_6.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167601-AXL
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- AXL
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- AXL receptor tyrosine kinase
- Biological Process
- Differentiation, Host-virus interaction, Immunity, Innate immunity
- Molecular Function
- Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Plasma membrane, Vesicles, Actin filaments
- Introduction
- The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.
- Alternative Names
- ARK, JTK11, Tyro7, UFO
- Gene ID
- 558
- UniProt ID
- P30530
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-1098CL | Anti-Human AXL Recombinant Antibody (Humanized 11B7) | ELISA, FuncS | Humanized antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1071CLV | Human Anti-AXL Recombinant Antibody (TAB-1071CLV) | ADCC, FuncS | Chimeric (mouse/human) IgG1, κ |
| TAB-1072CLV | Human Anti-AXL Recombinant Antibody (TAB-1072CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
| TAB-1073CLV | Human Anti-AXL Recombinant Antibody (TAB-1073CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
| TAB-1074CLV | Human Anti-AXL Recombinant Antibody (TAB-1074CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
| TAB-1075CLV | Human Anti-AXL Recombinant Antibody (TAB-1075CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1783LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1783LY-S(P)) | ELISA, IHC | Mouse scFv |
| HPAB-1850LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1850LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| HPAB-1851LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1851LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
| HPAB-1852LY-S(P) | Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1852LY-S(P)) | ELISA, IA, FC, IHC, WB, IP | Mouse scfv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1850LY-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1850LY-F(E)) | ELISA, IA, FC, IHC, WB, IP | Mouse Fab |
| HPAB-1851LY-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1851LY-F(E)) | ELISA, IA, FC, IHC, WB, IP | Mouse Fab |
| HPAB-1852LY-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1852LY-F(E)) | ELISA, IA, FC, IHC, WB, IP | Mouse Fab |
| HPAB-1853LY-F(E) | Mouse Anti-AXL Recombinant Antibody; Fab Fragment (HPAB-1853LY-F(E)) | ELISA, IA, FC, IHC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS3-XY108 | Mouse Anti-AXL Recombinant Antibody (clone 7E10) | ELISA, WB, ICC | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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