Anti-Human AXL Recombinant Antibody (Hz1613F12)

Name: Anti-Human AXL Recombinant Antibody (Hz1613F12)
SKU: TAB-1094CL
Rating: 5 (1 reviews)

CAT#: TAB-1094CL

The anti-AXL antibody Hz1613F12 targets AXL. The antibody can be used in the treatment of cancers, such as breast cancer, NSCLC, pancreas cancer, lung cancer and renal cancer

Published Data Gene Expression

ELISA

Figure 1 ELISA experiments studying binding on rhAxl-Fc protein of both m1613F12 and hz1613F12.

Figure 2 Binding of hz1613F12 and hz1613F12-24 DAR4 and DAR2 to SN12C human renal tumor cells as determined by FACS analysis. Data represent the mean intensity of fluorescence obtained over a range dose of antibody or ADC.

ELISA

Figure 3 Binding of hz1613F12 and of hz1613F12-24 DAR4 and hz1613F12-24 DAR2 on rhAxl-Fc immobilized protein as determined by ELISA. Data represent the optical densities obtained over a range dose of the tested antibodies. Data were analysed using Prism application.

Figure 4 Binding of hz1613F12 and hz1613F12-33 DAR4 to SN12C human renal tumor cells as determined by FACS analysis. Data represent the mean intensity of fluorescence obtained over a range dose of antibody or ADC.

ELISA

Figure 5 Binding of hz1613F12 and of hz1613F12-33 DAR4 on rhAxl-Fc immobilized protein as determined by ELISA. Data represent the optical densities obtained over a range dose of the tested antibodies. Data were analysed using Prism application.

Cyt

Figure 6 Concentration response cytotoxicity curves for hz1613F12-24 in Axl+SN12C (●) and in the control Axl- MCF7 (□) cell lines. A-at Day 3, B-at Day 6. Values of the EC₅₀ concentration was determined using Prism application with the regression analysis for each curve.

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Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, actin filaments & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75217/1899_C1_1_selected.jpg

Normal Tissue Figure 2 IHC staining of human thyroid gland

Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32501/ihc_selected.jpg

Normal Tissue Figure 3 Skeletal muscle

Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_B_1_6.jpg

Normal Tissue Figure 4 Colon

Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_8_3.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_9_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37422/82809_A_4_6.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, U-251 MG)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167601-AXL

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Specifications

Host Species
Human

Type
Humanized antibody

Specificity
Human

Clone
Hz1613F12

Applications
ELISA, FC, Cyt

Related Disease
Breast cancer, NSCLC, Pancreas cancer, Lung cancer, Renal cancer

Applications

Application Notes
This antibody as been tested for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry and Cytotoxicity.

Target

Alternative Names
AXL; AXL receptor tyrosine kinase; ARK; UFO; JTK11; Tyro7

Gene ID
558

UniProt ID
P30530

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-1094CL.pdf

MSDS

MSDS - TAB-1094CL.pdf

COA

Certificate of Analysis Lookup

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HPAB-1853LY-S(P)	Mouse Anti-AXL Recombinant Antibody; scFv Fragment (HPAB-1853LY-S(P))	ELISA, IA, FC, IHC, WB, IP	Mouse scfv
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