At Creative Biolabs, we take pride in providing cutting-edge AXL-targeted recombinant antibodies to researchers worldwide. With a dedication to excellence and continuous innovation, we support your scientific endeavors by providing superior products and exceptional technical support. Collaborate with us to propel your research forward and achieve ground-breaking results efficiently.
AXL, a receptor tyrosine kinase within the TAM family that includes TYRO3 and MERTK, plays a crucial role in normal tissues by aiding the clearance of apoptotic cells and moderating TLR-mediated inflammatory responses and natural killer cell activity. Recently, AXL has been identified as a significant driver of immune evasion and drug resistance in cancer cells, leading to the progression of aggressive cancers such as triple-negative breast cancer (TNBC), acute myeloid leukemia (AML), non-small-cell lung cancer (NSCLC), pancreatic cancer, and ovarian cancer. This makes AXL a promising target for the development of new cancer therapies.
Our advanced platforms enable our experienced research team to develop and offer a range of innovative and high-quality recombinant antibody products. We ensure robust quality control and provide top-notch technical support to empower our customers to apply our products to their meaningful projects with exceptional value.
Cat. No. | Product Name | Target Species | Host Species | Applications |
HPAB-M0416-YC | Human Anti-AXL Recombinant Antibody | Human | Human IgG | ELISA |
MOB-2240z | Mouse Anti-AXL Recombinant Antibody (clone 23F11) | Human | Mouse IgG1 | WB, ELISA, IF, IHC |
HPAB-0110-LS | Mouse Anti-AXL Recombinant Antibody | Human | Mouse IgG | WB, Agonist, ELISA, FC, SPR, FuncS |
TAB-1086CLV | Human Anti-AXL Recombinant Antibody | Human | Chimeric (mouse/human) IgG1, κ | ELISA |
TAB-1099CL | Anti-Human AXL Recombinant Antibody (Humanized 11D5) | Human | Humanized antibody | ELISA |
We are deeply committed to the biopharmaceutical community and strive to provide unwavering support for research and development. Our focus on superior product quality and unmatched customer support is evident in everything we do. We are committed to achieving total customer satisfaction through our rigorous and thorough quality control system. Our products are engineered to exceed industry standards, enabling the efficient development of medications and delivering exceptional value to our customers.
Fig.1 Anti-AXL Recombinant Antibody in SDS-PAGE.
(Cat# HPAB-0110-LS, Creative Biolabs).
Fig.2 Anti-AXL Recombinant Antibody in WB.
(Cat# HPAB-0110-LS, Creative Biolabs).
Fig.3 Anti-AXL Recombinant Antibody in HPLC.
(Cat# HPAB-M0416-YC, Creative Biolabs).
Fig.4 Anti-AXL Recombinant Antibody in SDS-PAGE.
(Cat# HPAB-M0416-YC, Creative Biolabs).
We offer an advanced serum-free mammalian cell expression system that covers every step from gene synthesis to the scalable production of high-quality anti-AXL recombinant antibodies. With over five years of expertise in optimizing these processes, we deliver rapid and cost-effective solutions designed to meet fluctuating antibody supply needs within a short turnaround time.
Featured Anti-AXL Recombinant Antibody Production Platforms
Fig.5 Milligram-scale anti-AXL recombinant antibody production.
Fig.6 Gram-scale anti-AXL recombinant antibody production.
At Creative Biolabs, we specialize in providing cutting-edge recombinant antibody solutions tailored to the unique requirements of the research community. Our portfolio of anti-AXL recombinant antibodies encompasses a range of formats, including full-length, Fab, scFv, and more. Leveraging our comprehensive antibody engineering expertise and years of experience, we are devoted to providing tailored solutions that propel your research goals forward.
Fig.7 Full-Length Anti-AXL Recombinant Antibody Production and Modalities
AZF; AZFA; SP3; AZF1; ARK; JTK11; Tyro7; UFO; AXL receptor tyrosine kinase.
Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Membrane
Cell type enhanced (Sertoli cells, Kupffer cells, Langerhans cells, Smooth muscle cells, Fibroblasts, Prostatic glandular cells)
Immune cell enhanced (plasmacytoid DC, NK-cell)
Cell line enhanced (fHDF/TERT166, U-251 MG)
Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.
Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Table 1. AXL-targeted drug information.
Company | Highest Phase | Classification | Condition |
3D Medicines Aravive (Originator) Aravive Biologics (Aravive) |
Phase III |
Fc Fusion Proteins Polypeptides, from 41 AA |
Cancer Cancer, bladder (urothelial carcinoma) Cancer, breast Cancer, fallopian tube Cancer, kidney (renal cell carcinoma, clear cell) Cancer, ovary Cancer, pancreas Cancer, pancreas (adenocarcinoma) Cancer, solid tumor Carcinoma, primary peritoneal (ovarian) Fibrosis IgA nephropathy Infection, Zika virus Myeloid leukemia |
BioAtla (Originator) | Phase II |
Antibodies Antibody-Drug Conjugates (ADCs) Auristatins Cancer Immunotherapy |
Cancer, lung (non-small cell) (NSCLC) Cancer, ovary Cancer, pancreas Cancer, pancreas (ductal adenocarcinoma) Cancer, prostate (castration-resistant) Cancer, solid tumor Osteosarcoma Sarcoma Soft tissue sarcoma |
EXUMA Biotech (Originator) Shanghai PerHum Therapeutics Sinobioway Sunterra Biotechnology (Shanghai PerHum Therapeutics) |
Phase I/II |
Cancer Immunotherapy Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) |
Cancer, kidney (renal cell carcinoma), metastatic Sarcoma |
Arcus Biosciences (Originator) | Phase I | Chemosensitizers |
Cancer Cancer, lung (non-small cell) (NSCLC) |
BerGenBio (Originator) Bergen Teknologioverfoering (Originator) |
Phase I |
Cancer Immunotherapy Humanized Monoclonal Antibodies |
Cancer |
ADC Therapeutics (Originator) Overland ADCT BioPharma |
Phase I |
Antibody-Drug Conjugates (ADCs) Cancer Immunotherapy Humanized Monoclonal Antibodies Pyrrolobenzodiazepines |
Acute lymphocytic leukemia Cancer, breast Cancer, esophagus Cancer, head and neck Cancer, lung (non-small cell) (NSCLC) Cancer, ovary Cancer, pancreas Cancer, solid tumor Cancer, stomach Mesothelioma, malignant Non-Hodgkin lymphoma Soft tissue sarcoma |
SSY Group (Originator) | IND Filed |
Cancer, liver Cancer, lung Cancer, prostate Cancer, solid tumor Cancer, stomach |
|
Universitair Ziekenhuis Brussel (Originator) Vrije Universiteit Brussel (VUB) (Originator) |
Preclinical |
Cancer Immunotherapy Fc Fusion Proteins Nuclear Imaging Agents Polypeptides, from 41 AA Radioimmunoconjugates Radiopharmaceuticals Single-Domain Antibodies Technetium Complexes |
Acute myeloid leukemia |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Please feel free to reach out to us at your earliest convenience if you would like to learn more about our anti-AXL recombinant antibody products.
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For Research Use Only. Not For Clinical Use.