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The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

Predicted location


Single cell type specificity

Cell type enhanced (Sertoli cells, Kupffer cells, Langerhans cells, Smooth muscle cells, Fibroblasts, Prostatic glandular cells)

Immune cell specificity

Immune cell enhanced (plasmacytoid DC, NK-cell)

Cell line specificity

Cell line enhanced (fHDF/TERT166, U-251 MG)


Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.

Molecular function

Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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